ArticleJournal of magnetic resonance (San Diego, Calif. : 1997)2013
Experimental issues in the measurement of multi-component relaxation times in articular cartilage by microscopic MRI.
Article in Journal of magnetic resonance (San Diego, Calif. : 1997), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 34 citations in OpenAlex.
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- Quantitative 3D Ultrashort Echo Time Magnetization Transfer Imaging for Evaluation of Knee Cartilage Degeneration In Vivo.Journal of magnetic resonance imaging : JMRI · 2021Article
- Bi-component T2 mapping correlates with articular cartilage material properties.Journal of biomechanics · 2021Article
- Low-field and variable-field NMR relaxation studies of H2O and D2O molecular dynamics in articular cartilage.PloS one · 2021Article
- Assessment of mechanical properties of articular cartilage with quantitative three-dimensional ultrashort echo time (UTE) cones magnetic resonance imaging.Journal of biomechanics · 2020Article
- Multi-vendor multi-site TOsteoarthritis and cartilage · 2020Article
- Resolution-dependent influences of compressed sensing in quantitative T2 mapping of articular cartilage.NMR in biomedicine · 2020Article
- Characterization complex collagen fiber architecture in knee joint using high-resolution diffusion imaging.Magnetic resonance in medicine · 2020Article
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- Quantitative measurement of T2, T1ρ and T1 relaxation times in articular cartilage and cartilage-bone interface by SE and UTE imaging at microscopic resolution.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2018Article
- Pulsed gradient stimulated echo (PGStE) NMR shows spatial dependence of fluid diffusion in human stage IV osteoarthritic cartilage.Magnetic resonance in medicine · 2018Article
- Compressed sensing in quantitative determination of GAG concentration in cartilage by microscopic MRI.Magnetic resonance in medicine · 2018Article
- Rapid simultaneous high-resolution mapping of myelin water fraction and relaxation times in human brain using BMC-mcDESPOT.NeuroImage · 2017Article
- The influences of different spatial resolutions on the characteristics of T2 relaxation times in articular cartilage: A coarse-graining study of the microscopic magnetic resonance imaging data.Microscopy research and technique · 2016Article
- Analysis of mcDESPOT- and CPMG-derived parameter estimates for two-component nonexchanging systems.Magnetic resonance in medicine · 2016Article
- MRI properties of a unique hypo-intense layer in degraded articular cartilage.Physics in medicine and biology · 2015Article
- T2 Relaxation time quantitation differs between pulse sequences in articular cartilage.Journal of magnetic resonance imaging : JMRI · 2015Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
A number of experimental issues in the measurement of multi-component T2 and T1ρ relaxations in native and enzymatically digested articular cartilage were investigated by microscopic MRI (μMRI). The issues included the bath solutions (physiological saline and phosphate buffered saline (PBS)), the imaging resolution (35-140 μm), the specimen orientations (0° and 55°), and the strength of spin-lock frequencies (0.5-2 kHz) in the T1ρ experiments. In addition to cartilage, the samples of agar gel and doped water solution were also used in the investigation. Two imaging sequences were used: CPMG-SE and MSME. All raw data were analyzed by the non-negative least square (NNLS) method. The MSME sequence was shown to result in the observation of multi-component T2, even in the gel and liquid samples, demonstrating the artificial uncleanness of this sequence in the multi-component measurements. The soaking of cartilage in PBS reduced the observable T2 components to one at both 0° and 55°, suggesting the effect of phosphate ions on proton exchange between different pools of water molecules. The cartilage orientation with respect to the external magnetic field and the spin-lock strengths in the T1ρ experiment both affected the quantification of the multi-component relaxation. The transitions between a mono-component and multi-components in cartilage under various experimental conditions call for the extra caution in interpreting the relaxation results.
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