ArticleExperimental gerontology2013
Role of PGC-1α in exercise training- and resveratrol-induced prevention of age-associated inflammation.
Article in Experimental gerontology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men.The Journal of physiology · 2014Trial
- Exercise following joint distraction inhibits muscle wasting and delays the progression of post-traumatic osteoarthritis in rabbits by activating PGC-1α in skeletal muscle.Journal of orthopaedic surgery and research · 2024Article
- Effects and Mechanisms of Resveratrol on Aging and Age-Related Diseases.Oxidative medicine and cellular longevity · 2021Review
- Modulation of MicroRNAs as a Potential Molecular Mechanism Involved in the Beneficial Actions of Physical Exercise in Alzheimer Disease.International journal of molecular sciences · 2020Review
- Combined Black Rice Germ, Bran Supplement and Exercise Intervention Modulate Aging Biomarkers and Improve Physical Performance and Lower-Body Muscle Strength Parameters in Aging Population.International journal of environmental research and public health · 2020Article
- Biochemical and Molecular Mechanisms of Glucose Uptake Stimulated by Physical Exercise in Insulin Resistance State: Role of Inflammation.Arquivos brasileiros de cardiologia · 2019Review
- Dynamic transcriptomic analysis reveals suppression of PGC1α/ERRα drives perturbed myogenesis in facioscapulohumeral muscular dystrophy.Human molecular genetics · 2019Article
- Sudden Death in Young Brazilian Athletes: Isn't It Time We Created a Genuinely National Register?Arquivos brasileiros de cardiologia · 2018Article
- The Potential Mechanisms of Exercise-induced Cognitive Protection: A Literature Review.Current pharmaceutical design · 2018Review
- PGC-1Physiological reports · 2017Article
- Calorie restriction as an intervention in ageing.The Journal of physiology · 2016Review
- PGC-1α promotes exercise-induced autophagy in mouse skeletal muscle.Physiological reports · 2016Article
- Dietary Antioxidants as Modifiers of Physiologic Adaptations to Exercise.Medicine and science in sports and exercise · 2015Review
- AMP-activated protein kinase controls exercise training- and AICAR-induced increases in SIRT3 and MnSOD.Frontiers in physiology · 2015Article
- Experimental studies of the molecular pathways regulated by exercise and resveratrol in heart, skeletal muscle and the vasculature.Molecules (Basel, Switzerland) · 2014Review
- The many roles of PGC-1α in muscle--recent developments.Metabolism: clinical and experimental · 2014Review
- Loss of Pgc-1α expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation.American journal of physiology. Endocrinology and metabolism · 2014Article
- Reversing Aging and Improving Health Span in Glaucoma Patients: The Next Frontier?Journal of current glaucoma practiceArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
BACKGROUND/
aimAge-related metabolic diseases are often associated with low-grade inflammation. The aim of the present study was to investigate the role of the transcriptional co-activator PGC-1α in the potential beneficial effects of exercise training and/or resveratrol in the prevention of age-associated low-grade inflammation. To address this, a long-term voluntary exercise training and resveratrol supplementation study was conducted. EXPERIMENTAL SETUP: Three month old whole body PGC-1α KO and WT mice were randomly assigned to four groups: untrained chow-fed, untrained chow-fed supplemented with resveratrol, chow-fed voluntarily exercise trained and chow-fed supplemented with resveratrol and voluntarily exercise trained. The intervention lasted 12 months and three month old untrained chow-fed mice served as young controls.
resultsVoluntary exercise training prevented an age-associated increase (p<0.05) in systemic IL-6 and adiposity in WT mice. PGC-1α expression was required for a training-induced prevention of an age-associated increase (p<0.05) in skeletal muscle TNFα protein. Independently of PGC-1α, both exercise training and resveratrol prevented an age-associated increase (p<0.05) in skeletal muscle protein carbonylation.
conclusionThe present findings highlight that exercise training is a more effective intervention than resveratrol supplementation in reducing age-associated inflammation and that PGC-1α in part is required for the exercise training-induced anti-inflammatory effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.