Evidence map›Paper›PMID 23916838›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2014

Epitope-based DNA vaccine for Alzheimer's disease: translational study in macaques.

Claire F Evans, Hayk Davtyan, Irina Petrushina, Armine Hovakimyan, Arpine Davtyan, Drew Hannaman, David H Cribbs, Michael G Agadjanyan, Anahit Ghochikyan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Claire F EvansIchor Medical Systems, San Diego, CA, USA.
Hayk DavtyanDepartment of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, CA, USA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
Irina PetrushinaInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
Armine HovakimyanDepartment of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, CA, USA.
Arpine DavtyanDepartment of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, CA, USA.
Drew HannamanIchor Medical Systems, San Diego, CA, USA.
David H CribbsInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA; Department of Neurology, University of California, Irvine, Irvine, CA, USA.
Michael G AgadjanyanDepartment of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, CA, USA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA. Electronic address: magadjanyan@immed.org.
Anahit GhochikyanDepartment of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, CA, USA.
University of California, Irvine · USInstitute for Molecular Medicine · USIchor Medical Systems (United States) · US

Funding

UC Irvine Alzheimer's Disease Research Center Induced Pluripotent Stem Cell CoreP50AG016573 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI LAFERLA, FRANK M · 2000 to 2019
$37.0M
Training in the Neurobiology of Aging and Alzheimers DiseaseT32AG000096 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI VIVEK SWARUP, Craig E Stark · 1985 to 2026
$9.6M
Combining AD Epitope Vaccine with Innate ImmunityR01NS050895 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI AGADJANYAN, MICHAEL G, CRIBBS, DAVID HASTINGS · 2004 to 2018
$7.4M
A Therapeutic DNA Epitope Vaccine for Alzheimer's DiseaseU44NS065518 · NINDS · ICHOR MEDICAL SYSTEMS, INC. · PI EVANS, CLAIRE FRANCES · 2009 to 2013
$1.8M
NIA NIH HHS P50 AG016573NIA NIH HHS P50-AG16573NIA NIH HHS T32 AG000096NINDS NIH HHS R01 NS050895NINDS NIH HHS U44 NS065518NINDS NIH HHS U44NS065518
6 · The paper itself

Abstract

backgroundClinical trials with passive and active Alzheimer's disease (AD) vaccines suggest that early interventions are needed for improvement of cognitive and/or functional performance in patients, providing impetus for the development of safe and immunologically potent active vaccines targeting amyloid β (Aβ). The AN-1792 trial has indicated that Aβ-specific T cells may be unsafe for humans; therefore, other vaccines based on small Aβ epitopes are undergoing preclinical and clinical testing.

methodsHumoral and cellular immune responses elicited in response to a novel DNA epitope-based vaccine (AV-1955) delivered to rhesus macaques using the TriGrid electroporation device were evaluated. Functional activities of anti-Aβ antibodies generated in response to vaccination were assessed in vitro.

resultsAV-1955 generates long-term, potent anti-Aβ antibodies and cellular immune responses specific to foreign T-helper epitopes but not to self-Aβ.

conclusionsThis translational study demonstrates that a DNA-based epitope vaccine for AD could be appropriate for human clinical testing.

Indexed as

Lymphocyte ActivationAlzheimer DiseaseAlzheimer VaccinesAmyloid beta-PeptidesAnimalsAntibodiesCell Line, TumorDose-Response Relationship, ImmunologicEpitopes, T-LymphocyteHumansImmunoglobulin GLongitudinal StudiesMacaca mulattaMalePlaque, AmyloidRandom AllocationAlzheimer VaccinesAmyloid beta-PeptidesAntibodiesEpitopes, T-LymphocyteImmunoglobulin GVaccines, DNAAlzheimer's diseaseAmyloid betaAntibody responseCellular immune responseDNA vaccineElectroporationEpitope vaccineRhesus macaquesTranslational

Identifiers

PMID23916838
PMCPMC3825833
OpenAlexW2033931958

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.