ArticleBrain research2013
Sleep allostasis in chronic sleep restriction: the role of the norepinephrine system.
Article in Brain research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Sleep matters: the U-shaped relationship between sleep duration and overactive bladder in U.S. adults.Frontiers in medicine · 2025Article
- Sleep-mediated regulation of reward circuits: implications in substance use disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Functional Connectivity Disturbances of the Locus Coeruleus in Chronic Insomnia Disorder.Nature and science of sleep · 2022Article
- Article
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- The effect of alpha-2 adrenergic receptors on memory retention deficit induced by rapid eye movement sleep deprivation.Iranian journal of basic medical sciences · 2020Article
- Sleep, brain vascular health and ageing.GeroScience · 2020Review
- Acute sleep deprivation during pregnancy in rats: Rapid elevation of placental and fetal inflammation and kynurenic acid.Neurobiology of stress · 2020Article
- Pumilio Regulates Sleep Homeostasis in Response to Chronic Sleep Deprivation inFrontiers in neuroscience · 2020Article
- Urinary Metabolomic Study of Chlorogenic Acid in a Rat Model of Chronic Sleep Deprivation Using Gas Chromatography-Mass Spectrometry.International journal of genomics · 2018Article
- Differential modulation of global and local neural oscillations in REM sleep by homeostatic sleep regulation.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Leukocyte Expression of Type 1 and Type 2 Purinergic Receptors and Pro-Inflammatory Cytokines during Total Sleep Deprivation and/or Sleep Extension in Healthy Subjects.Frontiers in neuroscience · 2017Article
- Cognitive Impacts of Estrogen Treatment in Androgen-Deprived Males: What Needs to be Resolved.Current neuropharmacology · 2017Review
- Beyond Emotional and Spatial Processes: Cognitive Dysfunction in a Depressive Phenotype Produced by Long Photoperiod Exposure.PloS one · 2017Article
- Chronic sleep restriction induces long-lasting changes in adenosine and noradrenaline receptor density in the rat brain.Journal of sleep research · 2015Article
- Sleep and REM sleep disturbance in the pathophysiology of PTSD: the role of extinction memory.Biology of mood & anxiety disorders · 2015Article
- Wake-active neurons across aging and neurodegeneration: a potential role for sleep disturbances in promoting disease.SpringerPlus · 2015Article
- Chronic sleep restriction elevates brain interleukin-1 beta and tumor necrosis factor-alpha and attenuates brain-derived neurotrophic factor expression.Neuroscience letters · 2014Article
- A review of sleep deprivation studies evaluating the brain transcriptome.SpringerPlus · 2014Review
- Chronic sleep restriction induces changes in the mandibular condylar cartilage of rats: roles of Akt, Bad and Caspase-3.International journal of clinical and experimental medicine · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Sleep responses to chronic sleep restriction may be very different from those observed after acute total sleep deprivation. Specifically, when sleep restriction is repeated for several consecutive days, animals express attenuated compensatory increases in sleep time and intensity during daily sleep opportunities. The neurobiological mechanisms underlying these adaptive, or more specifically, allostatic, changes in sleep homeostasis are unknown. Several lines of evidence indicate that norepinephrine may play a key role in modulating arousal states and NREM EEG delta power, which is widely recognized as a marker for sleep intensity. Therefore, we investigated time course changes in brain adrenergic receptor mRNA levels in response to chronic sleep restriction using a rat model. Here, we observed that significantly altered mRNA levels of the α1- adrenergic receptor in the basal forebrain as well as α2- and β1-adrenergic receptor in the anterior cingulate cortex only on the first sleep restriction day. On the other hand, the frontal cortex α1-, α2-, and β1-adrenergic receptor mRNA levels were reduced throughout the period of sleep restriction. Combined with our earlier findings on EEG that sleep time and intensity significantly increased only on the first sleep restriction days, these results suggest that alterations in the brain norepinephrine system in the basal forebrain and cingulate cortex may mediate allostatic changes in sleep time and intensity observed during chronic sleep restriction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.