Evidence map›Paper›PMID 23916425›Full record

ReviewMethods (San Diego, Calif.)2014

Investigating cockroach allergens: aiming to improve diagnosis and treatment of cockroach allergic patients.

Anna Pomés, Luisa Karla Arruda

Open access · greenAbstract readReview
In one paragraph

Review in Methods (San Diego, Calif.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 82 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Allergic rhinitis co-morbidity on asthma outcomes in city school children.The Journal of asthma : official journal of the Association for the Care of Asthma · 2023
    Article
  6. In Silico Comparative Exploration of Allergens ofMolecules (Basel, Switzerland) · 2022
    Article
  7. The first reported case of Blaptica dubia cockroach allergy.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2021
    Article
  8. Article
  9. Article
  10. Article
  11. Bedroom Allergen Exposure Beyond House Dust Mites.Current allergy and asthma reports · 2018
    Review
  12. Article
  13. Article
  14. New Insights into Cockroach Allergens.Current allergy and asthma reports · 2017
    Review
  15. Different Bla-g T cell antigens dominate responses in asthma versus rhinitis subjects.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2015
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Recombinant allergens for diagnosis of cockroach allergy.Current allergy and asthma reports · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Anna PomésIndoor Biotechnologies, Inc., Charlottesville, VA, USA. Electronic address: apomes@inbio.com.
Luisa Karla ArrudaSchool of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil.
Indoor Biotechnologies (United States) · USUniversidade de São Paulo · BR

Funding

Antigenic determinants of asthma-associated allergens for design of immunotherapy.R01AI077653 · NIAID · INDOOR BIOTECHNOLOGIES · PI MARTIN D. CHAPMAN, Maksymilian Chruszcz · 2009 to 2026
$9.5M
NIAID NIH HHS R01 AI077653NIAID NIH HHS R01AI077653
6 · The paper itself

Abstract

Cockroach allergy is an important health problem associated with the development of asthma, as a consequence of chronic exposure to low levels of allergens in susceptible individuals. In the last 20 years, progress in understanding the disease has been possible, thanks to the identification and molecular cloning of cockroach allergens and their expression as recombinant proteins. Assays for assessment of environmental allergen exposure have been developed and used to measure Bla g 1 and Bla g 2, as markers of cockroach exposure. IgE antibodies to cockroach extracts and to specific purified allergens have been measured to assess sensitization and analyze association with exposure and disease. With the development of the field of structural biology and the expression of recombinant cockroach allergens, insights into allergen structure, function, epitope mapping and allergen-antibody interactions have provided further understanding of mechanisms of cockroach allergic disease at the molecular level. This information will contribute to develop new approaches to allergen avoidance and to improve diagnosis and therapy of cockroach allergy.

Indexed as

AllergensAnimalsAsthmaCockroachesEnvironmental ExposureHumansImmunotherapyInsect ProteinsPrevalenceRecombinant ProteinsAllergensInsect ProteinsRecombinant ProteinsAsthmaCockroach allergyDiagnosisEnvironmental exposureImmunotherapyRecombinant allergens

Identifiers

PMID23916425
PMCPMC3909726
OpenAlexW2087283042

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.