Evidence map›Paper›PMID 23916149›Full record

ArticleBioorganic & medicinal chemistry2013

Investigation of acyclic uridine amide and 5'-amido nucleoside analogues as potential inhibitors of the Plasmodium falciparum dUTPase.

Shahienaz E Hampton, Alessandro Schipani, Cristina Bosch-Navarrete, Eliseo Recio, Marcel Kaiser, Pia Kahnberg, Dolores González-Pacanowska, Nils Gunnar Johansson, Ian H Gilbert

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

Shahienaz E HamptonDivision of Biological Chemistry and Drug Discovery, College of Life Science, University of Dundee, Sir James Black Centre, UK.
Alessandro Schipani
Cristina Bosch-Navarrete
Eliseo Recio
Marcel Kaiser
Pia Kahnberg
Dolores González-Pacanowska
Nils Gunnar Johansson
Ian H Gilbert
Parque Tecnológico de la Salud · ESUniversity of Dundee · GBMedivir (Sweden) · SESwiss Tropical and Public Health Institute · CH

Funding

Wellcome Trust WT083481
6 · The paper itself

Abstract

Previously we have shown that trityl and diphenyl deoxyuridine derivatives and their acyclic analogues can inhibit Plasmodium falciparum dUTPase (PfdUTPase). We report the synthesis of conformationally restrained amide derivatives as inhibitors PfdUTPase, including both acyclic and cyclic examples. Activity was dependent on the orientation and location of the amide constraining group. In the case of the acyclic series, we were able to obtain amide-constrained analogues which showed similar or greater potency than the unconstrained analogues. Unfortunately these compounds showed lower selectivity in cellular assays.

Indexed as

AmidesAntimalarialsEnzyme InhibitorsKineticsNucleosidesPlasmodium falciparumProtein BindingProtozoan ProteinsPyrophosphatasesUridineAmidesAntimalarialsdUTP pyrophosphataseEnzyme InhibitorsNucleosidesProtozoan ProteinsPyrophosphatasesUridine

Identifiers

PMID23916149
PMCPMC3776224
OpenAlexW2086823679

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.