ArticleNeurobiology of aging2013
Relationship of cognitive reserve and cerebrospinal fluid biomarkers to the emergence of clinical symptoms in preclinical Alzheimer's disease.
Article in Neurobiology of aging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cognitive Reserve, Alzheimer's Neuropathology, and Risk of Dementia: A Systematic Review and Meta-Analysis.Neuropsychology review · 2021Pooled it
- A Systematic Review of Longitudinal Studies Which Measure Alzheimer's Disease Biomarkers.Journal of Alzheimer's disease : JAD · 2017Pooled it
- Modeling the age-specific incidence of mild cognitive impairment incorporating the time-varying relationship of Alzheimer's disease biomarkers over 28 years.Journal of Alzheimer's disease : JAD · 2026Article
- An Update on Neuroaging on Earth and in Spaceflight.International journal of molecular sciences · 2025Review
- Identifying longitudinal cognitive resilience from cross-sectional amyloid, tau, and neurodegeneration.Alzheimer's research & therapy · 2024Article
- Actigraphy Estimated Sleep Moderates the Relationship between Physical Activity and Cognition in Older Adults.Mental health and physical activity · 2024Article
- Left Frontoparietal Control Network Connectivity Moderates the Effect of Amyloid on Cognitive Decline in Preclinical Alzheimer's Disease: The A4 Study.The journal of prevention of Alzheimer's disease · 2024Article
- Review
- Alzheimer's disease genetic risk and cognitive reserve in relationship to long-term cognitive trajectories among cognitively normal individuals.Alzheimer's research & therapy · 2023Article
- Getting the brain into gear: An online study investigating cognitive reserve and word-finding abilities in healthy ageing.PloS one · 2023Article
- Explaining the association between social and lifestyle factors and cognitive functions: a pathway analysis in the Memento cohort.Alzheimer's research & therapy · 2022Article
- Age-Dependent Association Between Cognitive Reserve Proxy and Longitudinal White Matter Microstructure in Older Adults.Frontiers in psychology · 2022Article
- Association of Lifestyle Activities with Functional Brain Connectivity and Relationship to Cognitive Decline among Older Adults.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Generalizability of findings from a clinical sample to a community-based sample: A comparison of ADNI and ARIC.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Article
- Longitudinal Analysis of Brain-Predicted Age in Amnestic and Non-amnestic Sporadic Early-Onset Alzheimer's Disease.Frontiers in aging neuroscience · 2021Article
- Cognitive reserve and midlife vascular risk: Cognitive and clinical outcomes.Annals of clinical and translational neurology · 2020Article
- Cognitive Reserve from the Perspective of Preclinical Alzheimer Disease: 2020 Update.Clinics in geriatric medicine · 2020Review
- Cognitive reserve and rate of change in Alzheimer's and cerebrovascular disease biomarkers among cognitively normal individuals.Neurobiology of aging · 2020Article
- Article
- Prediction of rapid amyloid and phosphorylated‐Tau accumulation in cognitively healthy individuals.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
Corrections and comments
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9 authors.
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Abstract
The levels of β-amyloid (Aβ) and phosphorylated tau (p-tau), as measured in cerebrospinal fluid, have been associated with the risk of progressing from normal cognition to onset of clinical symptoms during preclinical Alzheimer's disease. We examined whether cognitive reserve (CR) modifies this association. Cerebrospinal fluid was obtained at baseline from 239 participants (mean age, 57.2 years) who had been followed for up to 17 years with clinical and cognitive assessments (mean follow-up, 8 years). A composite score based on the National Adult Reading Test, vocabulary, and years of education at baseline was used as an index of CR. Cox regression models showed that the increased risk of progressing from normal cognition to symptom onset was associated with lower CR, lower baseline Aβ, and higher baseline p-tau. There was no interaction between CR and Aβ, suggesting that the protective effects of higher CR are equivalent across the observed range of amyloid levels. In contrast, both tau and p-tau interacted with CR, indicating that CR was more protective at lower levels of tau and p-tau.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.