ReviewTrends in genetics : TIG2013
How old is my gene?
Review in Trends in genetics : TIG, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Article
- Evolution of the Metazoan Protein Domain Repertoire Revealed by a Birth-Death-Gain Model.Journal of molecular evolution · 2025Article
- Bridging-Induced Phase Separation and Loop Extrusion Drive Noise in Chromatin Transcription.Physical review letters · 2025Article
- Article
- GETdb: A comprehensive database for genetic and evolutionary features of drug targets.Computational and structural biotechnology journal · 2024Article
- ContScout: sensitive detection and removal of contamination from annotated genomes.Nature communications · 2024Article
- Open Genes-a new comprehensive database of human genes associated with aging and longevity.Nucleic acids research · 2024Article
- Towards understanding paleoclimate impacts on primate de novo genes.G3 (Bethesda, Md.) · 2023Article
- Function and Constraint in Enhancer Sequences with Multiple Evolutionary Origins.Genome biology and evolution · 2022Article
- A Thermodynamic Model for Water Activity and Redox Potential in Evolution and Development.Journal of molecular evolution · 2022Article
- Decoding the effects of synonymous variants.Nucleic acids research · 2021Article
- Cancer progression as a sequence of atavistic reversions.BioEssays : news and reviews in molecular, cellular and developmental biology · 2021Article
- Evolutionary Analysis of the Bacillus subtilis Genome Reveals New Genes Involved in Sporulation.Molecular biology and evolution · 2020Article
- Eutherian-Specific Gene TRIML2 Attenuates Inflammation in the Evolution of Placentation.Molecular biology and evolution · 2020Article
- Autism risk genes are evolutionarily ancient and maintain a unique feature landscape that echoes their function.Autism research : official journal of the International Society for Autism Research · 2019Article
- GenTree, an integrated resource for analyzing the evolution and function of primate-specific coding genes.Genome research · 2019Article
- The Evolutionary Traceability of a Protein.Genome biology and evolution · 2019Article
- Evolutionarily novel genes are expressed in transgenic fish tumors and their orthologs are involved in development of progressive traits in humans.Infectious agents and cancer · 2019Article
- Ligand Binding Site Structure Influences the Evolution of Protein Complex Function and Topology.Cell reports · 2018Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Gene functions, interactions, disease associations, and ecological distributions are all correlated with gene age. However, it is challenging to estimate the intricate series of evolutionary events leading to a modern-day gene and then to reduce this history to a single age estimate. Focusing on eukaryotic gene families, we introduce a framework that can be used to compare current strategies for quantifying gene age, discuss key differences between these methods, and highlight several common problems. We argue that genes with complex evolutionary histories do not have a single well-defined age. As a result, care must be taken to articulate the goals and assumptions of any analysis that uses gene age estimates. Recent algorithmic advances offer the promise of gene age estimates that are fast, accurate, and consistent across gene families. This will enable a shift to integrated genome-wide analyses of all events in gene evolutionary histories in the near future.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.