Evidence map›Paper›PMID 23915713›Full record

ReviewThe Journal of allergy and clinical immunology2013

Viral infection of the lung: host response and sequelae.

Jae-Kwang Yoo, Taeg S Kim, Matthew M Hufford, Thomas J Braciale

Open access · bronzeAbstract readReview
In one paragraph

Review in The Journal of allergy and clinical immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 1 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 1 synthesis or guideline pooled it, 160 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Interferon regulatory factors orchestrate CD8International journal of molecular medicine · 2026
    Review
  7. Review
  8. Sex Differences in Lung Immunity.Immunological reviews · 2026
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. The role of innate immune system in respiratory viral infection related asthma.Frontiers in cellular and infection microbiology · 2025
    Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review

35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Jae-Kwang YooBeirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, Va.
Taeg S Kim
Matthew M Hufford
Thomas J Braciale
Carter Center · USUniversity of Virginia · US

Funding

Women's Oncology Program - WONP30CA044579 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Thomas P. Loughran · 1987 to 2026
$72.1M
INTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007496 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Michael G. Brown, Coleen A McNamara · 1995 to 2026
$10.2M
Regulation of CD8+ T cell responses via liver NK-DC crosstalkU19AI083024 · NIAID · UNIVERSITY OF VIRGINIA · PI ENELOW, RICHARD I · 2009 to 2013
$8.1M
Immunology and Infectious Diseases Training ProgramT32AI060519 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI MARK H KAPLAN · 2004 to 2026
$6.0M
CYTOTOXIC T LYMPHOCYTE RESPONSE TO INFLUENZA VIRUSR01AI015608 · NIAID · WASHINGTON UNIVERSITY · PI BRACIALE, THOMAS J · 1985 to 2017
$5.7M
T Cell Function in Pulmonary Viral Pulmonary Infection and InjuryR01HL033391 · NHLBI · WASHINGTON UNIVERSITY · PI BRACIALE, THOMAS J · 1985 to 2012
$4.3M
Global Biothreats Training ProgramT32AI055432 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI CRISS, ALISON K, PETRI, WILLIAM A · 2003 to 2022
$4.0M
NCI NIH HHS P30 CA044579NHLBI NIH HHS R01 HL033391NIAID NIH HHS R01 AI015608NIAID NIH HHS T32 AI007496NIAID NIH HHS T32 AI055432NIAID NIH HHS T32 AI060519NIAID NIH HHS U19 AI083024
6 · The paper itself

Abstract

Because of its essential role in gas exchange and oxygen delivery, the lung has evolved a variety of strategies to control inflammation and maintain homeostasis. Invasion of the lung by pathogens (and in some instances exposure to certain noninfectious particulates) disrupts this equilibrium and triggers a cascade of events aimed at preventing or limiting colonization (and more importantly infection) by pathogenic microorganisms. In this review we focus on viral infection of the lung and summarize recent advances in our understanding of the triggering of innate and adaptive immune responses to viral respiratory tract infection, mechanisms of viral clearance, and the well-recognized consequences of acute viral infection complicating underlying lung diseases, such as asthma.

Indexed as

Host-Pathogen InteractionsAdaptive ImmunityAnimalsAsthmaHumansImmunity, InnateLungPneumonia, ViralAbsent in melanoma 2adaptive immunityAIM2Antigen-presenting cellAPCApoptosis-associated speck-like protein containing CARDASCB-cell immunityCTLCytotoxic CD8(+) T-cellDamage-associated molecular patternDAMPDCDendritic cellFollicular helper TGCGerminal centerHigh-mobility group box 1HMGB1IAVILCILC-IIInfluenza A virusinnate immunityInnate lymphoid cellInterferon regulatory factorIRFLAPCLate activator antigen-presenting cellMAVSMediastinal lymph nodeMitochondrial anti-viral signalingMLNNatural killerNKNLRP3Nod-like receptor family protein 3PAMPPathogen-associated molecular patternPattern recognition receptorPRRRegulatory TRespiratory syncytial virusRetinoic acid–inducible gene IRIG-IRIG-I–like receptorRLRRSVstem cellsT-cell immunityT(FH)tissue repairTLRToll-like receptorTregType II innate lymphoid cellviral clearanceViral sensor molecules

Identifiers

PMID23915713
PMCPMC3844062
OpenAlexW1995606588

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.