ArticleMolecular autism2013
Identification of an age-dependent biomarker signature in children and adolescents with autism spectrum disorders.
Article in Molecular autism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association of Peripheral Blood Levels of Cytokines With Autism Spectrum Disorder: A Meta-Analysis.Frontiers in psychiatry · 2021Pooled it
- C reactive protein elevation among children or among mothers' of children with autism during pregnancy, a review and meta-analysis.BMC psychiatry · 2020Pooled it
- Olink proteomics profiling platform reveals non-invasive inflammatory related protein biomarkers in autism spectrum disorder.Frontiers in molecular neuroscience · 2023Article
- Comprehensive Behavioral Phenotyping of a 16p11.2 Del Mouse Model for Neurodevelopmental Disorders.Autism research : official journal of the International Society for Autism Research · 2020Article
- Article
- Serum proteomic profiling for autism using magnetic bead-assisted matrix-assisted laser desorption ionization time-of-flight mass spectrometry: a pilot study.World journal of pediatrics : WJP · 2018Article
- Depletion of Stercobilin in Fecal Matter from a Mouse Model of Autism Spectrum Disorders.Metabolomics : Official journal of the Metabolomic Society · 2017Article
- Brief Report: The Negev Hospital-University-Based (HUB) Autism Database.Journal of autism and developmental disorders · 2017Article
- Serologic Markers of Autism Spectrum Disorder.Journal of molecular neuroscience : MN · 2017Review
- The neonatal levels of TSB, NSE and CK-BB in autism spectrum disorder from Southern China.Translational neuroscience · 2016Article
- Overexpression of Homer1a in the basal and lateral amygdala impairs fear conditioning and induces an autism-like social impairment.Molecular autism · 2016Article
- Role of genetics in pediatric inflammatory bowel disease.Inflammatory bowel diseases · 2014Review
- Subclinical inflammatory status in Rett syndrome.Mediators of inflammation · 2014Article
- Biomarkers in autism.Frontiers in psychiatry · 2014Review
- Proteomic analysis of post mortem brain tissue from autism patients: evidence for opposite changes in prefrontal cortex and cerebellum in synaptic connectivity-related proteins.Molecular autism · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAutism spectrum disorders (ASDs) are neurodevelopmental conditions with symptoms manifesting before the age of 3, generally persisting throughout life and affecting social development and communication. Here, we have investigated changes in protein biomarkers in blood during childhood and adolescent development.
methodsWe carried out a multiplex immunoassay profiling analysis of serum samples from 37 individuals with a diagnosis of ASD and their matched, non-affected siblings, aged between 4 and 18 years, to identify molecular pathways affected over the course of ASDs.
resultsThis analysis revealed age-dependent differences in the levels of 12 proteins involved in inflammation, growth and hormonal signaling.
conclusionsThese deviations in age-related molecular trajectories provide further insight into the progression and pathophysiology of the disorder and, if replicated, may contribute to better classification of ASD individuals, as well as to improved treatment and prognosis. The results also underline the importance of stratifying and analyzing samples by age, especially in ASD and potentially other developmental disorders.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.