Evidence map›Paper›PMID 23915375›Full record

ArticleMolecular pharmaceutics2013

Drug delivery interfaces in the 21st century: from science fiction ideas to viable technologies.

Beata Chertok, Matthew J Webber, Marc D Succi, Robert Langer

Abstract read
In one paragraph

Article in Molecular pharmaceutics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Neurochips: Considerations from a neurosurgeon's standpoint.Surgical neurology international · 2021
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Supramolecular PEGylation of biopharmaceuticals.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Polyethylene-oxide improves microcirculatory blood flow in a murine hemorrhagic shock model.International journal of clinical and experimental medicine · 2015
    Article
  18. Review
  19. Review
  20. Bionanotechnology and the future of glioma.Surgical neurology international · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Beata ChertokDepartment of Chemical Engineering and ‡Koch Institute for Integrative Cancer Research, MIT , Cambridge, Massachusetts 02139, United States.
Matthew J Webber
Marc D Succi
Robert Langer

Funding

PHOTOPOLYMERIZATION FOR NONINVASIVE CARTILAGE TISSUER01DE013023 · NIDCR · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LANGER, ROBERT SAMUEL · 1998 to 2019
$6.8M
Controlled Release of MacromoleculesR37EB000244 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LANGER, ROBERT SAMUEL · 2008 to 2017
$3.9M
High-Throughput Craniofacial tissue engineeringR01DE016516 · NIDCR · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LANGER, ROBERT SAMUEL · 2005 to 2014
$3.8M
Ultrasound Polymeric Drug DeliveryR01EB000351 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LANGER, ROBERT SAMUEL · 2002 to 2013
$3.0M
A platform for image-guided, magneto-acoustic gene therapy of pancreatic cancerF32EB015835 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI CHERTOK, BEATA · 2012 to 2012
$52k
NIBIB NIH HHS 1F32EB015835-01NIBIB NIH HHS F32 EB015835NIBIB NIH HHS R01 EB000351NIBIB NIH HHS R37 EB000244NIDCR NIH HHS R01 DE013023NIDCR NIH HHS R01 DE016516
6 · The paper itself

Abstract

Early science fiction envisioned the future of drug delivery as targeted micrometer-scale submarines and "cyborg" body parts. Here we describe the progression of the field toward technologies that are now beginning to capture aspects of this early vision. Specifically, we focus on the two most prominent types of systems in drug delivery: the intravascular micro/nano drug carriers for delivery to the site of pathology and drug-loaded implantable devices that facilitate release with the predefined kinetics or in response to a specific cue. We discuss the unmet clinical needs that inspire these designs, the physiological factors that pose difficult challenges for their realization, and viable technologies that promise robust solutions. We also offer a perspective on where drug delivery may be in the next 50 years based on expected advances in material engineering and in the context of future diagnostics.

Indexed as

Drug CarriersDrug Delivery SystemsHumansNanotechnologyTranslational Research, BiomedicalDrug Carriers

Identifiers

PMID23915375
PMCPMC3818793

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.