ArticleBMC genomics2013
Correlated mRNAs and miRNAs from co-expression and regulatory networks affect porcine muscle and finally meat properties.
Article in BMC genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 47 citations in OpenAlex.
- Article
- Genetic regulation and variation of fetal plasma metabolome in the context of sex, paternal breeds and variable fetal weight.Open biology · 2025Article
- Identification of Key Genes and Biological Pathways Associated with Skeletal Muscle Maturation and Hypertrophy inAnimals : an open access journal from MDPI · 2022Article
- Effects of hypoxia and reoxygenation on mitochondrial functions and transcriptional profiles of isolated brain and muscle porcine cells.Scientific reports · 2022Article
- Integrative analysis of microRNAs and mRNAs reveals the regulatory networks of triterpenoid saponin metabolism in Soapberry (Frontiers in plant science · 2022Article
- The intra-class heterogeneity of immunophenotyping and immune landscape in oesophageal cancer and clinical implications.Annals of medicine · 2021Article
- Genetic regulation and heritability of miRNA and mRNA expression link to phosphorus utilization and gut microbiome.Open biology · 2021Article
- Weighted Co-Expression Network Analysis Identifies RNF181 as a Causal Gene of Coronary Artery Disease.Frontiers in genetics · 2021Article
- Mitonuclear Interactions in the Maintenance of Mitochondrial Integrity.Life (Basel, Switzerland) · 2020Review
- The long noncoding RNA MyHC IIA/X-AS contributes to skeletal muscle myogenesis and maintains the fast fiber phenotype.The Journal of biological chemistry · 2020Article
- Identification of Four Potential Biomarkers Associated With Coronary Artery Disease in Non-diabetic Patients by Gene Co-expression Network Analysis.Frontiers in genetics · 2020Article
- Article
- Gene co-expression networks associated with carcass traits reveal new pathways for muscle and fat deposition in Nelore cattle.BMC genomics · 2019Article
- Detection of Co-expressed Pathway Modules Associated With Mineral Concentration and Meat Quality in Nelore Cattle.Frontiers in genetics · 2019Article
- An integrative transcriptome analysis indicates regulatory mRNA-miRNA networks for residual feed intake in Nelore cattle.Scientific reports · 2018Article
- Co-Expression Network Analysis Identifies miRNA⁻mRNA Networks Potentially Regulating Milk Traits and Blood Metabolites.International journal of molecular sciences · 2018Article
- miRNAs regulate acute transcriptional changes in broiler embryos in response to modification of incubation temperature.Scientific reports · 2018Article
- Integrative analysis of microRNAs and mRNAs revealed regulation of composition and metabolism in Nelore cattle.BMC genomics · 2018Article
- Gene Co-expression Analysis Indicates Potential Pathways and Regulators of Beef Tenderness in Nellore Cattle.Frontiers in genetics · 2018Article
- Genetic architecture and regulatory impact on hepatic microRNA expression linked to immune and metabolic traits.Open biology · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPhysiological processes aiding the conversion of muscle to meat involve many genes associated with muscle structure and metabolic processes. MicroRNAs regulate networks of genes to orchestrate cellular functions, in turn regulating phenotypes.
resultsWe applied weighted gene co-expression network analysis to identify co-expression modules that correlated to meat quality phenotypes and were highly enriched for genes involved in glucose metabolism, response to wounding, mitochondrial ribosome, mitochondrion, and extracellular matrix. Negative correlation of miRNA with mRNA and target prediction were used to select transcripts out of the modules of trait-associated mRNAs to further identify those genes that are correlated with post mortem traits.
conclusionsPorcine muscle co-expression transcript networks that correlated to post mortem traits were identified. The integration of miRNA and mRNA expression analyses, as well as network analysis, enabled us to interpret the differentially-regulated genes from a systems perspective. Linking co-expression networks of transcripts and hierarchically organized pairs of miRNAs and mRNAs to meat properties yields new insight into several biological pathways underlying phenotype differences. These pathways may also be diagnostic for many myopathies, which are accompanied by deficient nutrient and oxygen supply of muscle fibers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.