ArticleBMC gastroenterology2013
Leukocytosis and high hematocrit levels during abdominal attacks of hereditary angioedema.
Article in BMC gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
- C-reactive protein levels in hereditary angioedema.Clinical and experimental immunology · 2014Trial
- Abdominal attacks and treatment in hereditary angioedema with C1-inhibitor deficiency.BMC gastroenterology · 2014Trial
- Abdominal and pelvic imaging in the diagnosis of acute abdominal attacks in patients with hereditary angioedema due to C1-inhibitor deficiency.Postepy dermatologii i alergologii · 2022Article
- Serum fetuin-A, tumor necrosis factor alpha and C-reactive protein concentrations in patients with hereditary angioedema with C1-inhibitor deficiency.Orphanet journal of rare diseases · 2019Article
- Screening for hereditary angioedema (HAE) at 13 emergency centers in Osaka, Japan: A prospective observational study.Medicine · 2017Observational
- Hereditary angioedema (HAE): a cause for recurrent abdominal pain.BMJ case reports · 2016Article
- Growth factors and IL-17 in hereditary angioedema.Clinical and experimental medicine · 2016Article
- Diagnosis and screening of patients with hereditary angioedema in primary care.Therapeutics and clinical risk management · 2016Review
- Hereditary Angioedema and Gastrointestinal Complications: An Extensive Review of the Literature.Case reports in immunology · 2015Article
- Hereditary angioedema: what the gastroenterologist needs to know.Clinical and experimental gastroenterology · 2014Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe diagnosis of hereditary angioedema (HAE) is often delayed due to the low awareness of this condition. In patients with undiagnosed HAE, abdominal symptoms often create the risk of unnecessary surgical operation and/or drug therapy. To explore the cause of misdiagnosis, we compared the laboratory findings of HAE patients under normal conditions with those during abdominal attacks.
methodsPatient medical histories were analyzed and laboratory data at the first consultation with no symptoms and no medication were compared with those at visits to the emergency department during severe attacks.
resultsFourteen HAE patients were enrolled. Initial HAE symptoms occurred at 20.2 ± 9.4 years of age. The correct diagnosis of HAE was made 22.7 ± 14.2 years after the initial symptoms. A common site of angioedema was the extremities. Half of the patients experienced a life-threatening laryngeal attack and/or severe abdominal pain. In the patients with severe abdominal pain, significant leukocytosis with neutrophilia along with increased levels of hematocrit were observed while levels of C-reactive protein (CRP) remained low. All severe attacks were alleviated with an infusion of C1-inhibitor concentrate.
conclusionsConsideration of the likelihood of a HAE attack is important when patients present with acute abdominal pain and leukocytosis without elevation of CRP.
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