ArticleAlcoholism, clinical and experimental research2014
Prenatal alcohol exposure results in long-term serotonin neuron deficits in female rats: modulatory role of ovarian steroids.
Article in Alcoholism, clinical and experimental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Role of gut microbiota and its functional products in prenatal alcohol-induced anxiety-like behavior.Progress in neuro-psychopharmacology & biological psychiatry · 2025Article
- Chemogenetic inhibition of prefrontal cortex inputs to dorsal raphe reduces anxiety behaviors in male rat model of fetal alcohol spectrum disorder.Scientific reports · 2025Article
- Article
- Prenatal and postnatal insults differentially contribute to executive function and cognition: Utilizing touchscreen technology for perinatal brain injury research.Experimental neurology · 2022Article
- Prenatal Alcohol Exposure and Pair Feeding Differentially Impact Puberty and Reproductive Development in Female Rats: Role of the Kisspeptin System.Alcoholism, clinical and experimental research · 2016Article
- Serotonergic Neuroplasticity in Alcohol Addiction.Brain plasticity (Amsterdam, Netherlands) · 2016Review
- Third Trimester Equivalent Alcohol Exposure Reduces Modulation of Glutamatergic Synaptic Transmission by 5-HT1A Receptors in the Rat Hippocampal CA3 Region.Frontiers in neuroscience · 2016Article
- Prenatal Alcohol Exposure in Rodents As a Promising Model for the Study of ADHD Molecular Basis.Frontiers in neuroscience · 2016Review
- Prenatal alcohol exposure alters methyl metabolism and programs serotonin transporter and glucocorticoid receptor expression in brain.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Neurotoxicity of prenatal alcohol exposure on medullary pre-Bötzinger complex neurons in neonatal rats.Neural regeneration research · 2015Article
- Docosahexaenoic acid partially ameliorates deficits in social behavior and ultrasonic vocalizations caused by prenatal ethanol exposure.Behavioural brain research · 2015Article
- Article
- Genetic and early environmental influences on the serotonin system: consequences for brain development and risk for psychopathology.Journal of psychiatry & neuroscience : JPN · 2015Review
- Eye movements reveal sexually dimorphic deficits in children with fetal alcohol spectrum disorder.Frontiers in neuroscience · 2015Article
- Construction of vapor chambers used to expose mice to alcohol during the equivalent of all three trimesters of human development.Journal of visualized experiments : JoVE · 2014Article
- Circadian rhythms and addiction: mechanistic insights and future directions.Behavioral neuroscience · 2014Review
- Bovine Brain: An in vitro Translational Model in Developmental Neuroscience and Neurodegenerative Research.Frontiers in pediatrics · 2014Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundPrevious studies on male rodents found that prenatal alcohol exposure (PAE) decreases the number of serotonin immunoreactive (5-HT-ir) neurons in the brainstem. However, data on the effects of PAE in females are lacking. In light of known sex differences in responsiveness of the 5-HT system and known effects of estrogen (E2 ) and progesterone (P4 ) in the brain, we hypothesized that sex steroids will modulate the adverse effects of PAE on 5-HT neurons in adult females.
methodsAdult females from 3 prenatal groups (Prenatal alcohol-exposed [PAE], Pair-fed [PF], and ad libitum-fed Controls [C]) were ovariectomized (OVX), with or without hormone replacement, or underwent Sham OVX. 5-HT-ir cells were examined in key brainstem areas.
resultsOur data support the hypothesis that PAE has long-term effects on the 5-HT system of females and that ovarian steroids have a modulatory role in these effects. Intact (Sham OVX) PAE females had marginally lower numbers of 5-HT-ir neurons in the dorsal raphe nucleus of the brainstem compared with PF and C females. This marginal difference became significant following removal of hormones by OVX. Replacement with E2 restored the number of 5-HT-ir neurons in PAE females to control levels, while P4 reversed the effects of E2 . Importantly, despite these differential responses of the 5-HT system to ovarian steroids, there were no differences in E2 and P4 levels among prenatal treatment groups.
conclusionsThese data demonstrate long-term, adverse effects of PAE on the 5-HT system of females, as well as differential sensitivity of PAE compared with control females to the modulatory effects of ovarian steroids on 5-HT neurons. Our findings have important implications for understanding sex differences in 5-HT dysfunction in depression/anxiety disorders and the higher rates of these mental health problems in individuals with fetal alcohol spectrum disorder.
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