ArticleThe Journal of experimental biology2013
RNA-Seq reveals early distinctions and late convergence of gene expression between diapause and quiescence in the Asian tiger mosquito, Aedes albopictus.
Article in The Journal of experimental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- microRNA profiles and functions in mosquitoes.PLoS neglected tropical diseases · 2018Pooled it
- Insect Lipids: Structure, Classification and Function.Advances in experimental medicine and biology · 2026Review
- Natural variation in timing of egg hatching, response to water agitation, and bidirectional selection of early and late hatching strains of the malaria mosquito Anopheles gambiae sensu lato.Parasites & vectors · 2024Article
- Glucose influence cold tolerance in the fall armyworm, Spodoptera frugiperda via trehalase gene expression.Scientific reports · 2024Article
- Characterization of pre-diapause phase in the northern Drosophila species D. ezoana.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Article
- Role of vector phenotypic plasticity in disease transmission as illustrated by the spread of dengue virus by Aedes albopictus.Nature communications · 2024Article
- Temperature dependence of mosquitoes: Comparing mechanistic and machine learning approaches.PLoS neglected tropical diseases · 2024Article
- Comparison of distinct gut bacterial communities in different stage of prediapause and nondiapause larvae inFrontiers in microbiology · 2024Article
- RNA-Seq-Pop: Exploiting the sequence in RNA sequencing-A Snakemake workflow reveals patterns of insecticide resistance in the malaria vector Anopheles gambiae.Molecular ecology resources · 2023Article
- Temperature, season, and latitude influence development-related phenotypes of Philippine Aedes aegypti (Linnaeus): Implications for dengue control amidst global warming.Parasites & vectors · 2022Article
- A comparative analysis ofCurrent research in insect science · 2022Article
- Survival and Replication of Zika Virus in Diapause Eggs ofFrontiers in microbiology · 2022Article
- Maternally Instigated Diapause inFrontiers in behavioral neuroscience · 2022Review
- Endocrine Regulation of Lifespan in Insect Diapause.Frontiers in physiology · 2022Review
- When your host shuts down: larval diapause impacts host-microbiome interactions in Nasonia vitripennis.Microbiome · 2021Article
- A Linkage-Based Genome Assembly for the MosquitoInsects · 2021Article
- Genome-wide identification of Aedes albopictus long noncoding RNAs and their association with dengue and Zika virus infection.PLoS neglected tropical diseases · 2021Article
- Induction of long-lived potential aestivation states in laboratory An. gambiae mosquitoes.Parasites & vectors · 2020Article
- Monarch butterflies use an environmentally sensitive, internal timer to control overwintering dynamics.Molecular ecology · 2019Article
- Transcriptome Sequencing Reveals Potential Mechanisms of the Maternal Effect on Egg Diapause Induction ofInternational journal of molecular sciences · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Dormancy is a crucial adaptation allowing insects to withstand harsh environmental conditions. The pre-programmed developmental arrest of diapause is a form of dormancy that is distinct from quiescence, in which development arrests in immediate response to hardship. Much progress has been made in understanding the environmental and hormonal controls of diapause. However, studies identifying transcriptional changes unique to diapause, rather than quiescence, are lacking, making it difficult to disentangle the transcriptional profiles of diapause from dormancy in general. The Asian tiger mosquito, Aedes albopictus, presents an ideal model for such a study, as diapausing and quiescent eggs can be staged and collected for global gene expression profiling using a newly developed transcriptome. Here, we use RNA-Seq to contrast gene expression during diapause with quiescence to identify transcriptional changes specific to the diapause response. We identify global trends in gene expression that show gradual convergence of diapause gene expression upon gene expression during quiescence. Functionally, early diapause A. albopictus show strong expression differences of genes involved in metabolism, which diminish over time. Of these, only expression of lipid metabolism genes remained distinct in late diapause. We identify several genes putatively related to hormonal control of development that are persistently differentially expressed throughout diapause, suggesting these might be involved in the maintenance of diapause. Our results identify key biological differences between diapausing and quiescent pharate larvae, and suggest candidate pathways for studying metabolism and the hormonal control of development during diapause in other species.
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