ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2014
Chronic kidney disease defined by cystatin C predicts mobility disability and changes in gait speed: the Framingham Offspring Study.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Shared biological pathways for frailty and cognitive impairment: A systematic review.Ageing research reviews · 2018Pooled it
- Physical Function Decline Among Adults With Moderate-to-Severe CKD.Kidney international reports · 2026Article
- Klotho Deficiency Promotes Skeletal Muscle Weakness and Is Associated with Impaired Motor Unit Connectivity.International journal of molecular sciences · 2025Article
- Klotho deficiency promotes skeletal muscle weakness and is associated with impaired motor unit connectivity.bioRxiv : the preprint server for biology · 2025Article
- Lipoprotein(a) and Heart Failure Among Black and White Participants in Atherosclerosis Risk in Communities Study, Framingham Offspring Study, and Multi-Ethnic Study of Atherosclerosis: The Pooling Project.Journal of the American Heart Association · 2025Article
- Association of cystatin C kidney function measures with motoric cognitive risk syndrome: evidence from two cohort studies.The journal of nutrition, health & aging · 2025Article
- Association Between Frailty and Albuminuria in the Community-Dwelling Geriatric Population.Clinical interventions in aging · 2025Article
- Article
- Pharmacologic therapeutics in sarcopenia with chronic kidney disease.Kidney research and clinical practice · 2024Article
- Association of Cystatin C Kidney Function Measures With Long-term Deficit-Accumulation Frailty Trajectories and Physical Function Decline.JAMA network open · 2022Article
- The association between healthy aging index and trajectories of disability: a population-based cohort study.Aging clinical and experimental research · 2022Article
- Functional tests in patients with ischemic heart disease.Journal of medicine and life · 2022Article
- Sarcopenia in Chronic Kidney Disease: A Scoping Review of Prevalence, Risk Factors, Association with Outcomes, and Treatment.Calcified tissue international · 2022Article
- Preliminary Study of the Effects of Eccentric-Overload Resistance Exercise on Physical Function and Torque Capacity in Chronic Kidney Disease.Journal of functional morphology and kinesiology · 2020Article
- Shared mechanisms for cognitive impairment and physical frailty: A model for complex systems.Alzheimer's & dementia (New York, N. Y.) · 2020Article
- Serum creatinine and cystatin C-based index can be a screening biomarker for sarcopenia in older population.European geriatric medicine · 2019Article
- Social isolation in chronic kidney disease and the role of mobility limitation.Clinical kidney journal · 2019Article
- Assessment of physical functioning in the clinical care of the patient with advanced kidney disease.Seminars in dialysis · 2019Review
- Subjective Age and Cystatin C Among Older Adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2019Article
- Skeletal muscle fibrosis is associated with decreased muscle inflammation and weakness in patients with chronic kidney disease.American journal of physiology. Renal physiology · 2018Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAs creatinine-based estimates of renal function are inaccurate in older adults, an alternative is an estimated glomerular filtration rate (eGFR(cys)) based on cystatin C. We examined the prospective association between chronic kidney disease (CKD(cys)) as determined by eGFR(cys) with the primary outcome of incident mobility disability and the secondary outcome of change in gait speed.
methodsFramingham Offspring Study participants older than 60 years and free of mobility disability at baseline (1998-2001) were eligible. Baseline CKD(cys) was defined as eGFR(cys) less than 60 mL/min/1.73 m(2). At follow-up (2005-2008), the outcomes of mobility disability, defined as self-reported inability to walk 1/2 mile and/or climb a flight of stairs, and gait speed were measured. Logistic and linear regression models were adjusted for age, sex, body mass index, smoking, diabetes, C reactive protein, and physical activity.
resultsOf 1,226 participants, 230 (19%) had CKD(cys) at baseline. After a mean follow-up of 6.6 years, 185 (15%) developed mobility disability. Of those with CKD(cys), 60 (26%) developed mobility disability. Those with CKD(cys) had greater odds of mobility disability in the age- and sex-adjusted (odds ratio [OR] 1.91, 95% CI 1.32, 2.75) and fully adjusted (OR 1.55, 95% CI 1.05, 2.31) models compared with those without CKD(cys). In fully adjusted models, participants with CKD(cys) had greater gait speed declines than those without CKD(cys) (β = 0.07 [SE 0.02], p = .0022).
conclusionCKD(cys) was associated with higher odds of incident mobility disability and greater decline in gait speed, highlighting the loss of physical independence in elders with CKD.
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