ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2013
A staging system for the regeneration of a polyp from the aboral physa of the anthozoan Cnidarian Nematostella vectensis.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- Whole body regeneration deploys a rewired embryonic gene regulatory network logic.Nature communications · 2025Article
- LRRK2 kinase activity is necessary for development and regeneration in Nematostella vectensis.Neural development · 2024Article
- Evolution and Function of the Notch Signaling Pathway: An Invertebrate Perspective.International journal of molecular sciences · 2024Review
- LRRK2 kinase activity is necessary for development and regeneration in Nematostella vectensis.Research square · 2023Article
- Manipulation of Gene Activity in the Regenerative Model Sea Anemone, Nematostella vectensis.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Creating a User-Friendly and Open-Access Gene Expression Database for Comparing Embryonic Development and Regeneration in Nematostella vectensis.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Review
- Review
- Mesoglea Extracellular Matrix Reorganization during Regenerative Process inInternational journal of molecular sciences · 2021Article
- Characterization of the dynamics and variability of neuronal subtype responses during growth, degrowth, and regeneration of Nematostella vectensis.BMC biology · 2021Article
- Review
- Transcriptomic Analysis in the Sea Anemone Nematostella vectensis.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Review
- Cellular and Molecular Mechanisms of Hydra Regeneration.Results and problems in cell differentiation · 2019Review
- Inducing Complete Polyp Regeneration from the Aboral Physa of the Starlet Sea Anemone Nematostella vectensis.Journal of visualized experiments : JoVE · 2017Article
- A transcriptional time-course analysis of oral vs. aboral whole-body regeneration in the Sea anemone Nematostella vectensis.BMC genomics · 2016Article
- The rise of the starlet sea anemone Nematostella vectensis as a model system to investigate development and regeneration.Wiley interdisciplinary reviews. Developmental biology · 2016Review
- Diversity of Cnidarian Muscles: Function, Anatomy, Development and Regeneration.Frontiers in cell and developmental biology · 2016Review
- Characterization of Morphological and Cellular Events Underlying Oral Regeneration in the Sea Anemone, Nematostella vectensis.International journal of molecular sciences · 2015Article
- Evolution of the perlecan/HSPG2 gene and its activation in regenerating Nematostella vectensis.PloS one · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAs the sea anemone Nematostella vectensis emerges as a model for studying regeneration, new tools will be needed to assess its regenerative processes and describe perturbations resulting from experimental investigation. Chief among these is the need for a universal set of staging criteria to establish morphological landmarks that will provide a common format for discussion among investigators.
resultsWe have established morphological criteria to describe stages for rapidly assessing regeneration of the aboral end (physa) of Nematostella. Using this staging system, we observed rates of regeneration that are temperature independent during wound healing and temperature dependent afterward. Treatment with 25 μM lipoic acid delays the progression through wound healing without significantly affecting the subsequent rate of regeneration. Also, while an 11-day starvation before amputation causes only a minimal delay in regeneration, this delay is exacerbated by lipoic acid treatment.
conclusionsA system for staging the progression of regeneration in amputated Nematostella physa based on easily discernible morphological features provides a standard for the field. This system has allowed us to identify both temperature-dependent and -independent phases of regeneration, as well as a nutritional requirement for normal regenerative progression that is exacerbated by lipoic acid.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.