ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2014
"Self-regulation," a new facet of Hox genes' function.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Significance of Premature Vertebral Mineralization in Zebrafish Models in Mechanistic and Pharmaceutical Research on Hereditary Multisystem Diseases.Biomolecules · 2023Review
- Inference on autoregulation in gene expression with variance-to-mean ratio.Journal of mathematical biology · 2023Article
- baredSC: Bayesian approach to retrieve expression distribution of single-cell data.BMC bioinformatics · 2022Article
- Transcriptional Trajectories in Mouse Limb Buds Reveal the Transition from Anterior-Posterior to Proximal-Distal Patterning at Early Limb Bud Stage.Journal of developmental biology · 2020Article
- A Tribute to Lewis Wolpert and His Ideas on the 50th Anniversary of the Publication of His Paper 'Positional Information and the Spatial Pattern of Differentiation'. Evidence for a Timing Mechanism for Setting Up the Vertebrate Anterior-Posterior (A-P) Axis.International journal of molecular sciences · 2020Review
- The formation of the thumb requires direct modulation ofProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Hoxa13 regulates expression of common Hox target genes involved in cartilage development to coordinate the expansion of the autopodal anlage.Development, growth & differentiation · 2019Article
- Roles of Retinoic Acid Signaling in Shaping the Neuronal Architecture of the Developing Amphioxus Nervous System.Molecular neurobiology · 2018Article
- Two Tier Hox Collinearity Mediates Vertebrate Axial Patterning.Frontiers in cell and developmental biology · 2018Article
- On the Formation of Digits and Joints during Limb Development.Developmental cell · 2017Article
- Distal Limb Patterning Requires Modulation of cis-Regulatory Activities by HOX13.Cell reports · 2016Article
- Article
- HOX13 proteins: the molecular switcher in Hoxd bimodal regulation.Genes & development · 2016Article
- A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locus.Genes & development · 2016Article
- Review
- Geometric Morphometrics on Gene Expression Patterns Within Phenotypes: A Case Example on Limb Development.Systematic biology · 2016Article
- HoxA and HoxD expression in a variety of vertebrate body plan features reveals an ancient origin for the distal Hox program.EvoDevo · 2014Article
- Conservation and divergence of regulatory strategies at Hox Loci and the origin of tetrapod digits.PLoS biology · 2014Article
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Authors and funding
4 authors.
Funding
Abstract
backgroundPrecise temporal and spatial expression of the clustered Hox genes is essential for patterning the developing embryo. Temporal activation of Hox genes was shown to be cluster-autonomous. However, gene clustering appears dispensable for spatial colinear expression. Generally, a set of Hox genes expressed in a group of cells instructs these cells about their fate such that the differential expression of Hox genes results in morphological diversity. The spatial colinearity is considered to rely both on local and long-range cis regulation.
resultsHere, we report on the global deregulation of HoxA and HoxD expression patterns upon inactivation of a subset of HOXA and HOXD proteins.
conclusionsOur data suggest the existence of a "self-regulation" mechanism, a process by which HOX proteins establish and/or maintain the spatial domains of the Hox gene family and we propose that the functionally dominant HOX proteins could contribute to generating the spatial parameters of Hox expression in a given tissue, i.e., HOX controlling the establishment of the ultimate HOX code.
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