ArticleHuman brain mapping2014
Functional magnetic resonance imaging of working memory in Huntington's disease: cross-sectional data from the IMAGE-HD study.
Article in Human brain mapping, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- The Role of the Cerebellum in Huntington's Disease: a Systematic Review.Cerebellum (London, England) · 2021Pooled it
- Volumetric analysis of the hypothalamus in Huntington Disease using 3T MRI: the IMAGE-HD Study.PloS one · 2015Trial
- The cognitive cerebellum: a hub for motor, emotional, and executive control.Arquivos de neuro-psiquiatria · 2025Review
- Memory Function and Huntington's Disease: A Systematic Review.Neuropsychology review · 2025Review
- Cerebellum in Alzheimer's disease and other neurodegenerative diseases: an emerging research frontier.MedComm · 2024Review
- Prodromal Cognitive Changes as a Prognostic Indicator of Forthcoming Huntington's Disease Severity: A Retrospective Longitudinal Study.Movement disorders clinical practice · 2024Article
- Bridging Huntington's disease research with big data science: Harmonized neuroimaging datasets from multiple studies.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Neuroimaging to Facilitate Clinical Trials in Huntington's Disease: Current Opinion from the EHDN Imaging Working Group.Journal of Huntington's disease · 2024Review
- Investigating longitudinal changes to frontal cortico-striatal tracts in Huntington's disease: the IMAGE-HD study.Brain imaging and behavior · 2022Article
- Heat Shock Factor 1 Directly Regulates Postsynaptic Scaffolding PSD-95 in Aging and Huntington's Disease and Influences Striatal Synaptic Density.International journal of molecular sciences · 2021Article
- Dual tasking impairments are associated with striatal pathology in Huntington's disease.Annals of clinical and translational neurology · 2020Article
- An Examination of Psychomotor Disturbance in Current and Remitted MDD: An RDoC Study.Journal of psychiatry and brain science · 2020Article
- Working Memory-Related Effective Connectivity in Huntington's Disease Patients.Frontiers in neurology · 2018Article
- Activation volume vs BOLD signal change as measures of fMRI activation - Its impact on GABA - fMRI activation correlation.Magnetic resonance imaging · 2017Article
- Striatal morphology correlates with frontostriatal electrophysiological motor processing in Huntington's disease: an IMAGE-HD study.Brain and behavior · 2016Article
- Large-scale brain network abnormalities in Huntington's disease revealed by structural covariance.Human brain mapping · 2016Article
- Network topology and functional connectivity disturbances precede the onset of Huntington's disease.Brain : a journal of neurology · 2015Article
- T1ρ imaging in premanifest Huntington disease reveals changes associated with disease progression.Movement disorders : official journal of the Movement Disorder Society · 2015Article
- The role of the amygdala during emotional processing in Huntington's disease: from pre-manifest to late stage disease.Neuropsychologia · 2015Article
- Abnormal Electrophysiological Motor Responses in Huntington's Disease: Evidence of Premanifest Compensation.PloS one · 2015Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We used functional magnetic resonance imaging (fMRI) to investigate spatial working memory (WM) in an N-BACK task (0, 1, and 2-BACK) in premanifest Huntington's disease (pre-HD, n = 35), early symptomatic Huntington's disease (symp-HD, n = 23), and control (n = 32) individuals. Overall, both WM conditions (1-BACK and 2-BACK) activated a large network of regions throughout the brain, common to all groups. However, voxel-wise and time-course analyses revealed significant functional group differences, despite no significant behavioral performance differences. During 1-BACK, voxel-wise blood-oxygen-level-dependent (BOLD) signal activity was significantly reduced in a number of regions from the WM network (inferior frontal gyrus, anterior insula, caudate, putamen, and cerebellum) in pre-HD and symp-HD groups, compared with controls; however, time-course analysis of the BOLD response in the dorsolateral prefrontal cortex (DLPFC) showed increased activation in symp-HD, compared with pre-HD and controls. The pattern of reduced voxel-wise BOLD activity in pre-HD and symp-HD, relative to controls, became more pervasive during 2-BACK affecting the same structures as in 1-BACK, but also incorporated further WM regions (anterior cingulate gyrus, parietal lobe and thalamus). The DLPFC BOLD time-course for 2-BACK showed a reversed pattern to that observed in 1-BACK, with a significantly diminished signal in symp-HD, relative to pre-HD and controls. Our findings provide support for functional brain reorganisation in cortical and subcortical regions in both pre-HD and symp-HD, which are modulated by task difficulty. Moreover, the lack of a robust striatal BOLD signal in pre-HD may represent a very early signature of change observed up to 15 years prior to clinical diagnosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.