ArticleAmerican journal of physiology. Heart and circulatory physiology2013
Chronic baroreflex activation restores spontaneous baroreflex control and variability of heart rate in obesity-induced hypertension.
Article in American journal of physiology. Heart and circulatory physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Associations between novel triglyceride-glucose-related indices and the incidence of hypertension among Chinese middle-aged and elderly adults: a nationwide prospective cohort study.Cardiovascular diabetology. Endocrinology reports · 2025Article
- Sympathetic nervous system inhibition enhances cardiac metabolism and improves hemodynamics and glucose-insulin dynamics in obese and lean rat models.Scientific reports · 2025Article
- Mechanisms and treatment of obesity-related hypertension-Part 1: Mechanisms.Clinical kidney journal · 2024Review
- Interplay between baroreflex sensitivity, obesity and related cardiometabolic risk factors (Review).Experimental and therapeutic medicine · 2022Review
- Obesity, kidney dysfunction, and inflammation: interactions in hypertension.Cardiovascular research · 2021Review
- Endothelin B receptors impair baroreflex function and increase blood pressure variability during high salt diet.Autonomic neuroscience : basic & clinical · 2021Article
- Article
- Obesity, kidney dysfunction and hypertension: mechanistic links.Nature reviews. Nephrology · 2019Review
- Device-Based Neuromodulation for Resistant Hypertension Therapy.Circulation research · 2019Review
- Upregulation of Nav1.6 expression in the rostral ventrolateral medulla of stress-induced hypertensive rats.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Article
- Role of the heart in blood pressure lowering during chronic baroreflex activation: insight from an in silico analysis.American journal of physiology. Heart and circulatory physiology · 2018Article
- Ultra-short heart rate variability recording reliability: The effect of controlled paced breathing.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2018Article
- Reduced Renal Mass, Salt-Sensitive Hypertension Is Resistant to Renal Denervation.Frontiers in physiology · 2018Article
- Maternal separation diminishes α-adrenergic receptor density and function in renal vasculature from male Wistar-Kyoto rats.American journal of physiology. Renal physiology · 2017Article
- Baroreflex Activation Therapy in Congestive Heart Failure: Novel Findings and Future Insights.Current hypertension reports · 2016Review
- Chronic Interactions Between Carotid Baroreceptors and Chemoreceptors in Obesity Hypertension.Hypertension (Dallas, Tex. : 1979) · 2016Article
- Electrical carotid sinus stimulation: chances and challenges in the management of treatment resistant arterial hypertension.Current hypertension reports · 2015Review
- Effects of low-level carotid baroreflex stimulation on atrial electrophysiology.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2015Article
- Xyloketal B attenuates atherosclerotic plaque formation and endothelial dysfunction in apolipoprotein e deficient mice.Marine drugs · 2015Article
- The baroreflex as a long-term controller of arterial pressure.Physiology (Bethesda, Md.) · 2015Review
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Authors and funding
4 authors at 3 institutions in 2 countries.
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Abstract
The sensitivity of baroreflex control of heart rate is depressed in subjects with obesity hypertension, which increases the risk for cardiac arrhythmias. The mechanisms are not fully known, and there are no therapies to improve this dysfunction. To determine the cardiovascular dynamic effects of progressive increases in body weight leading to obesity and hypertension in dogs fed a high-fat diet, 24-h continuous recordings of spontaneous fluctuations in blood pressure and heart rate were analyzed in the time and frequency domains. Furthermore, we investigated whether autonomic mechanisms stimulated by chronic baroreflex activation and renal denervation-current therapies in patients with resistant hypertension, who are commonly obese-restore cardiovascular dynamic control. Increases in body weight to ∼150% of control led to a gradual increase in mean arterial pressure to 17 ± 3 mmHg above control (100 ± 2 mmHg) after 4 wk on the high-fat diet. In contrast to the gradual increase in arterial pressure, tachycardia, attenuated chronotropic baroreflex responses, and reduced heart rate variability were manifest within 1-4 days on high-fat intake, reaching 130 ± 4 beats per minute (bpm) (control = 86 ± 3 bpm) and ∼45% and <20%, respectively, of control levels. Subsequently, both baroreflex activation and renal denervation abolished the hypertension. However, only baroreflex activation effectively attenuated the tachycardia and restored cardiac baroreflex sensitivity and heart rate variability. These findings suggest that baroreflex activation therapy may reduce the risk factors for cardiac arrhythmias as well as lower arterial pressure.
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