Evidence map›Paper›PMID 23913363›Full record

ReviewJournal of cardiovascular translational research2013

Ultrasound contrast materials in cardiovascular medicine: from perfusion assessment to molecular imaging.

Alexander L Klibanov

Abstract readReview
In one paragraph

Review in Journal of cardiovascular translational research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Alexander L KlibanovDivision of Cardiovascular Medicine and Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA, sasha@virginia.edu.

Funding

Biomechanics of Leukocytes and Molecular Imaging AgentsR01EB002185 · NIBIB · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI LAWRENCE, MICHAEL BRANDEAU · 2003 to 2010
$5.7M
Image-guided Ultrasound-triggered Tumor TherapyR33CA102880 · NCI · UNIVERSITY OF VIRGINIA · PI KLIBANOV, ALEXANDER L · 2008 to 2011
$1.1M
Ultrasound Contrast Agents for Inflammation and AngiogenesisR44EB007857 · NIBIB · TARGESON, LLC · PI RYCHAK, JOSHUA J. · 2009 to 2010
$1.0M
Image-guided Ultrasound-triggered Tumor TherapyR21CA102880 · NCI · UNIVERSITY OF VIRGINIA · PI KLIBANOV, ALEXANDER L · 2007 to 2007
$205k
Ultrasound Contrast Agents for Inflammation and AngiogenesisR43EB007857 · NIBIB · TARGESON, LLC · PI RYCHAK, JOSHUA J. · 2008 to 2008
$100k
NCI NIH HHS R21/33CA102880NCI NIH HHS R21 CA102880NCI NIH HHS R33 CA102880NIBIB NIH HHS R01 EB002185NIBIB NIH HHS R01EB002185NIBIB NIH HHS R43/44 EB007857NIBIB NIH HHS R43 EB007857NIBIB NIH HHS R44 EB007857
6 · The paper itself

Abstract

Ultrasound imaging is widely used in cardiovascular diagnostics. Contrast agents expand the range of tasks that ultrasound can perform. In the clinic in the USA, endocardial border delineation and left ventricle opacification have been an approved indication for more than a decade. However, myocardial perfusion contrast ultrasound studies are still at the clinical trials stage. Blood pool contrast and perfusion in other tissues might be an easier indication to achieve: general blood pool ultrasound contrast is in wider use in Europe, Canada, Japan, and China. Targeted (molecular) contrast microbubbles will be the next generation of ultrasound imaging probes, capable of specific delineation of the areas of disease by adherence to molecular targets. The shell of targeted microbubbles (currently in the preclinical research and early stage clinical trials) is decorated with the ligands (antibodies, peptides or mimetics, hormones, and carbohydrates) that ensure firm binding to the molecular markers of disease.

Indexed as

Contrast MediaAnimalsCardiovascular DiseasesHumansMicrobubblesMolecular ImagingMyocardial Perfusion ImagingPerfusion ImagingPredictive Value of TestsPrognosisSeverity of Illness IndexUltrasonographyContrast Media

Identifiers

PMID23913363
PMCPMC3816116

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.