ArticleMolecular cancer research : MCR2013
Inhibition of cell adhesion by a cadherin-11 antibody thwarts bone metastasis.
Article in Molecular cancer research : MCR, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 43 citations in OpenAlex.
- Cadherin-1-mediated communication at the leader-follower boundary controls mouse breast tumor organoid collective migration.Cell reports · 2025Article
- Cdh11: Roles in different diseases and potential value in disease diagnosis and treatment.Biochemistry and biophysics reports · 2023Review
- Cadherin-11 increases tumor cell proliferation and metastatic potential via Wnt pathway activation.Molecular oncology · 2023Article
- Targeting breast and pancreatic cancer metastasis using a dual-cadherin antibody.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Roads to Stat3 Paved with Cadherins.Cells · 2022Review
- Upregulation of cadherin-11 contributes to cholestatic liver fibrosis.Pediatric investigation · 2022Article
- Prostate tumor-induced stromal reprogramming generates Tenascin C that promotes prostate cancer metastasis through YAP/TAZ inhibition.Oncogene · 2022Article
- Research progress in the role and mechanism of Cadherin-11 in different diseases.Journal of Cancer · 2021Review
- Clinical and prognostic association of oncogene cadherin 11 in gastric cancer.Oncology letters · 2020Article
- Cadherin-11 Is Required for Neural Crest Specification and Survival.Frontiers in physiology · 2020Article
- Promoter Hypermethylation of CHODL Contributes to Carcinogenesis and Indicates Poor Survival in Patients with Early-stage Colorectal Cancer.Journal of Cancer · 2020Article
- Cadherin-11 blockade reduces inflammation-driven fibrotic remodeling and improves outcomes after myocardial infarction.JCI insight · 2019Article
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- Cadherin Signaling in Cancer: Its Functions and Role as a Therapeutic Target.Frontiers in oncology · 2019Review
- Chalcone Derivatives 4'-Amino-1-Naphthyl-Chalcone (D14) and 4'-Amino-4-Methyl-1-Naphthyl-Chalcone (D15) Suppress Migration and Invasion of Osteosarcoma Cells Mediated by p53 Regulating EMT-Related Genes.International journal of molecular sciences · 2018Article
- Synthetic single domain antibodies for the conformational trapping of membrane proteins.eLife · 2018Article
- Androgen Receptor-CaMKK2 Axis in Prostate Cancer and Bone Microenvironment.Frontiers in endocrinology · 2018Review
- Tenascin-C and Integrin α9 Mediate Interactions of Prostate Cancer with the Bone Microenvironment.Cancer research · 2017Article
- Proteomics Profiling of Exosomes from Primary Mouse Osteoblasts under Proliferation versus Mineralization Conditions and Characterization of Their Uptake into Prostate Cancer Cells.Journal of proteome research · 2017Article
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
Abstract
unlabelledCadherin-11 (CDH11) is a member of the cadherin superfamily mainly expressed in osteoblasts but not in epithelial cells. However, prostate cancer cells with a propensity for bone metastasis express high levels of cadherin-11 and reduced levels of E-cadherin. Downregulation of cadherin-11 inhibits interaction of prostate cancer cells with osteoblasts in vitro and homing of prostate cancer cells to bone in an animal model of metastasis. These findings indicate that targeting cadherin-11 may prevent prostate cancer bone metastasis. To explore this possibility, a panel of 21 monoclonal antibodies (mAb) was generated against the extracellular (EC) domain of cadherin-11. Two antibodies, mAbs 2C7 and 1A5, inhibited cadherin-11-mediated cell-cell aggregation in vitro using L-cells transfected with cadherin-11. Both antibodies demonstrated specificity to cadherin-11, and neither antibody recognized E-cadherin or N-cadherin on C4-2B or PC3 cells, respectively. Furthermore, mAb 2C7 inhibited cadherin-11-mediated aggregation between the highly metastatic PC3-mm2 cells and MC3T3-E1 osteoblasts. Mechanistically, a series of deletion mutants revealed a unique motif, aa 343-348, in the cadherin-11 EC3 domain that is recognized by mAb 2C7 and that this motif coordinated cell-cell adhesion. Importantly, administration of mAb 2C7 in a prophylactic setting effectively prevented metastasis of PC3-mm2 cells to bone in an in vivo mouse model. These results show that targeting the extracellular domain of cadherin-11 can limit cellular adhesion and metastatic dissemination of prostate cancer cells. IMPLICATIONS: Monotherapy using a cadherin-11 antibody is a suitable option for the prevention of bone metastases.
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