ArticleJournal of neural transmission (Vienna, Austria : 1996)2014
Striatal volume is related to phonemic verbal fluency but not to semantic or alternating verbal fluency in early Parkinson's disease.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 49 citations in OpenAlex.
- Semantic and Phonological Brain Networks in Older Adults: A Systematic Scoping Review.Brain sciences · 2026Review
- The evolution of phonemic verbal fluency test: bridging tradition with contemporary insights.Frontiers in psychology · 2026Review
- Normative Data for the Famous People Fluency Test in the Adult French-Quebec Population and Validation Study in Mild Cognitive Impairment and Alzheimer's Disease.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025Article
- Speech and language biomarkers for Parkinson's disease prediction, early diagnosis and progression.NPJ Parkinson's disease · 2025Review
- Psychometrics and diagnostics of the Italian version of the Alternate Verbal Fluency Battery (AVFB) in non-demented Parkinson's disease patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Bridging the Gap: Association between Objective and Subjective Outcomes of Communication Performance in People with Parkinson's Disease Evaluated for Deep Brain Stimulation.Movement disorders clinical practice · 2023Article
- Italian reference values and brain correlates of verbal fluency index -Amyotrophic lateral sclerosis & frontotemporal degeneration · 2023Article
- Neural correlates of verbal fluency revealed by longitudinal T1, T2 and FLAIR imaging in stroke.NeuroImage. Clinical · 2023Article
- Semantic fluency deficits and associated brain activity in Parkinson's disease with mild cognitive impairment.Brain imaging and behavior · 2022Article
- Safety of Plasma Infusions in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2020Article
- The association of bone, fingernail and blood manganese with cognitive and olfactory function in Chinese workers.The Science of the total environment · 2019Article
- Clinical characteristics of cognitive impairment in patients with Parkinson's disease and its related pattern inHuman brain mapping · 2018Article
- Magnetic resonance imaging for the diagnosis of Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2017Review
- Cognitive or Cognitive-Motor Executive Function Tasks? Evaluating Verbal Fluency Measures in People with Parkinson's Disease.BioMed research international · 2017Article
- Longitudinal Study of Gray Matter Changes in Parkinson Disease.AJNR. American journal of neuroradiology · 2015Article
- Brain (18)F-DOPA PET and cognition in de novo Parkinson's disease.European journal of nuclear medicine and molecular imaging · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Verbal fluency impairments are frequent in Parkinson's disease (PD) and they may be present already at early stages. Semantic fluency impairment is associated with Parkinson's disease dementia and temporal, frontal and cerebellar cortical changes. Few studies have addressed cerebral structural correlates of different verbal fluency tasks in early stage PD. We therefore studied gray matter volumes of T1-weighted MRI images using voxel-based morphometry in relation to semantic, phonemic, and alternating verbal fluency in younger (mean age <65 years), early stage (mean disease duration <3 years), non-demented PD patients (n = 28) and healthy controls (n = 27). We found a significant association between worse phonemic fluency and smaller striatal, namely right caudate gray matter volume in the PD group only (family-wise error corrected p = 0.007). Reduced semantic fluency was associated with smaller gray matter volumes in left parietal cortex (p = 0.037) and at trend level with smaller bilateral cerebellum gray matter volume across groups (p = 0.062), but not in the separate PD or control groups. There were no significant relationships between alternating fluency and gray matter volumes in the whole sample or in the groups separately. The fact that phonemic fluency, but not semantic or alternating fluency, was associated with caudate gray matter volume at early stage PD suggests that different fluency tasks rely on different neural substrates, and that language networks supporting semantic search and verbal-semantic switching are unrelated to brain gray matter volume at early disease stages in PD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.