ArticleJournal of clinical immunology2013
Innate immune recognition of molds and homology to the inner ear protein, cochlin, in patients with autoimmune inner ear disease.
Article in Journal of clinical immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- The effect of lichen secondary metabolites on Aspergillus fungi.Archives of microbiology · 2021Pooled it
- Advances in biomarkers for differential diagnosis of autoimmune and autoinflammatory inner ear disorders.Molecular biology reports · 2026Review
- A pilot study on the effect of SARS-CoV-2 spike protein on IL-1β-mediated inflammation in peripheral blood immune cells from AIED patients.Molecular medicine (Cambridge, Mass.) · 2025Article
- Predicting the prognosis of patients with sudden sensorineural hearing loss by analyzing the audiometric curve of the unaffected ear.Frontiers in neurology · 2025Article
- Article
- COCH-related autosomal dominant nonsyndromic hearing loss: a phenotype-genotype study.Human genetics · 2022Article
- Advances in otolith-related protein research.Frontiers in neuroscience · 2022Review
- Biomarkers for Inner Ear Disorders: Scoping Review on the Role of Biomarkers in Hearing and Balance Disorders.Diagnostics (Basel, Switzerland) · 2020Article
- miR‑10b‑3p, miR‑8112 and let‑7j as potential biomarkers for autoimmune inner ear diseases.Molecular medicine reports · 2019Article
- The Price of Immune Responses and the Role of Vitamin D in the Inner Ear.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2019Review
- Proinflammatory cytokines and response to molds in mononuclear cells of patients with Meniere disease.Scientific reports · 2018Article
- Review
- Article
- AAO: Autoimmune and Autoinflammatory (Disease) in Otology: What is New in Immune-Mediated Hearing Loss.Laryngoscope investigative otolaryngology · 2016Review
- Toll-like receptor 4 modulates the cochlear immune response to acoustic injury.Cell death & disease · 2016Article
- Clinical Subgroups in Bilateral Meniere Disease.Frontiers in neurology · 2016Article
- Mechanisms of sensorineural cell damage, death and survival in the cochlea.Frontiers in aging neuroscience · 2015Review
- The state of vestibular neurology: Diagnostic challenges and emerging opportunities.Science progressReview
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Autoimmune Inner Ear Disease (AIED) is characterized by bilateral, fluctuating sensorineural hearing loss with periods of hearing decline triggered by unknown stimuli. Here we examined whether an environmental exposure to mold in these AIED patients is sufficient to generate a pro-inflammatory response that may, in part, explain periods of acute exacerbation of disease. We hypothesized that molds may stimulate an aberrant immune response in these patients as both several Aspergillus species and penecillium share homology with the LCCL domain of the inner ear protein, cochlin. We showed the presence of higher levels of anti-mold IgG in plasma of AIED patients at dilution of 1:256 (p = 0.032) and anti-cochlin IgG 1:256 (p = 0.0094 and at 1:512 p = 0.024) as compared with controls. Exposure of peripheral blood mononuclear cells (PBMC) of AIED patients to mold resulted in an up-regulation of IL-1β mRNA expression, enhanced IL-1β and IL-6 secretion, and generation of IL-17 expressing cells in mold-sensitive AIED patients, suggesting mold acts as a PAMP in a subset of these patients. Naïve B cells secreted IgM when stimulated with conditioned supernatant from AIED patients' monocytes treated with mold extract. In conclusion, the present studies indicate that fungal exposure can trigger autoimmunity in a subset of susceptible AIED patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.