Evidence map›Paper›PMID 23912754›Full record

ArticlePaediatric drugs2013

Pharmacologically assisted treatment of opioid-dependent youth.

Anna Pecoraro, Marc Fishman, Michelle Ma, Gvantsa Piralishvili, George E Woody

Abstract read
PubMed Publisher
In one paragraph

Article in Paediatric drugs, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Extended-release naltrexone for youth with opioid use disorder.Journal of substance abuse treatment · 2021
    Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Anna PecoraroDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 600 Public Ledger Building, 150 South Independence Mall West, Philadelphia, PA, 19106-3413, USA.
Marc Fishman
Michelle Ma
Gvantsa Piralishvili
George E Woody
University of Pennsylvania · USJohns Hopkins University · USUniversity of Michigan–Ann Arbor · US

Funding

Delaware Valley Node of the Clinical Trials NetworkU10DA013043 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI WOODY, GEORGE EDWARD · 1999 to 2015
$25.8M
Treatment/Substance Use Disorders/HIV Risk ReductionK05DA017009 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI WOODY, GEORGE EDWARD · 2003 to 2012
$1.3M
Suboxone and Methadone for HIV Risk Reduction in Subutex InjectorsR21DA026754 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI WOODY, GEORGE EDWARD · 2009 to 2010
$347k
NIDA NIH HHS KO5 DA-17009NIDA NIH HHS R01 DA02455301NIDA NIH HHS R21-DA-026754NIDA NIH HHS U10 DA-13043
6 · The paper itself

Abstract

Opioid misuse, abuse, and dependence are global problems whose patterns vary across cultures. In the USA, the non-medical use of prescription opioids has become particularly serious because of its association with addiction and overdose death. Agonist and antagonist medications have been shown to be effective for opioid-dependent adults, and there is a growing body of data that they are also effective for youth. Here, we summarize evidence that detoxification alone results in high rates of treatment dropout and relapse but that the limited but growing data on the extended use of medication-assisted treatment for opioid-dependent youth have been positive. The implementation of medication-assisted treatment as a standard practice is feasible, easily integrated with counseling or psychotherapy, and has potential to greatly improve outcomes. Although concerns about safety and efficacy with youth require more research, and we do not advocate indefinite maintenance, we suggest that opioid-dependent youth should be considered as candidates for medication-assisted treatment delivered in a comprehensive, developmentally appropriate context, beginning at the first episode of care, with the strength of the recommendation to use medication increasing with each care episode.

Indexed as

AdolescentAnalgesics, OpioidHumansNarcotic AntagonistsOpioid-Related DisordersPsychotherapyAnalgesics, OpioidNarcotic Antagonists

Identifiers

PMID23912754
OpenAlexW2037732477

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.