SynthesisNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2014
Voxelwise meta-analysis of white matter abnormalities in progressive supranuclear palsy.
Synthesis in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Atrophy in midbrain & cerebral/cerebellar pedunculi is characteristic for progressive supranuclear palsy - A double-validation whole-brain meta-analysis.NeuroImage. Clinical · 2019Pooled it
- Voxel-based meta-analysis of gray and white matter volume abnormalities in spinocerebellar ataxia type 2.Brain and behavior · 2018Pooled it
- Voxel-Based Morphometry of Progressive Supranuclear Palsy Using a 3D Fast Low-angle Shot Localizer Image: A Comparison with Magnetization-Prepared Rapid Gradient Echo.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025Article
- In vivo binding of a tau imaging probe, [Movement disorders : official journal of the Movement Disorder Society · 2019Article
- Beyond the midbrain atrophy: wide spectrum of structural MRI finding in cases of pathologically proven progressive supranuclear palsy.Neuroradiology · 2017Review
- Repeatability of Brain Volume Measurements Made with the Atlas-based Method from TMagnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2016Article
- The utility of neuroimaging in the differential diagnosis of parkinsonian syndromes.Seminars in neurology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
White matter deficits constitute one element of the network dysfunction that underlies progressive supranuclear palsy (PSP). Cumulative evidence of white matter abnormalities in patients with PSP has been reported using voxel-based morphometry (VBM), but these studies have not been quantitatively reviewed and not all findings have been entirely concordant. Whole-brain VBM studies comparing PSP patients with healthy controls (HC) were systematically searched in the PubMed and EMABSE databases from January 1990 to April 2013. Coordinates with significant differences in the white matter volume (WMV) between PSP patients and HC were extracted from each cluster. A meta-analysis was performed using anatomic likelihood estimation. Ten studies with a total of 159 PSP patients and 236 HC were included in the meta-analysis. WMV reductions were observed in the midbrain, pons and the regions close to the basal ganglia. No WMV increase was reported. Meta-regression showed both MMSE and UPDRS III scores correlated with WM changes in the regions from bilateral midbrain to basal ganglia. Our findings provide evidence for white matter atrophy in the midbrain, pons and several regions near the basal ganglia, representing the main pathophysiology of PSP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.