Evidence map›Paper›PMID 23912686›Full record

ReviewCurrent atherosclerosis reports2013

Atherosclerosis and transit of HDL through the lymphatic vasculature.

Catherine Martel, Gwendalyn J Randolph

Abstract readReview
In one paragraph

Review in Current atherosclerosis reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Frontiers in immunology · 2023
    Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Lymphatics in the liver.Current opinion in immunology · 2018
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Lymphatic transport of high-density lipoproteins and chylomicrons.The Journal of clinical investigation · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Catherine MartelDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. cmartel@path.wustl.edu
Gwendalyn J Randolph
Washington University in St. Louis · US

Funding

Cholesterol and Lymphatic Transport of Molecules and CellsR01HL096539 · NHLBI · WASHINGTON UNIVERSITY · PI RANDOLPH, GWENDALYN J, SWARTZ, MELODY ANN · 2009 to 2012
$1.5M
NHLBI NIH HHS R01 HL096539
6 · The paper itself

Abstract

Key components of atherosclerotic plaque known to drive disease progression are macrophages and cholesterol. It has been widely understood, and bolstered by recent evidence, that the efflux of cholesterol from macrophage foam cells quells disease progression or even to promote regression. Following macrophage cholesterol efflux, cholesterol loaded onto HDL must be removed from the plaque environment. Here, we focus on recent evidence that the lymphatic vasculature is critical for the removal of cholesterol, likely as a component of HDL, from tissues including skin and the artery wall. We discuss the possibility that progression of atherosclerosis might in part be linked to sluggish removal of cholesterol from the plaque.

Indexed as

AtherosclerosisBiological TransportCholesterolHumansLipoproteins, HDLLymph NodesPlaque, AtheroscleroticCholesterolLipoproteins, HDL

Identifiers

PMID23912686
PMCPMC3799774
OpenAlexW2050157170

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.