ArticleJournal of physiology and biochemistry2014
Oxytocin activates calcium signaling in rat sensory neurons through a protein kinase C-dependent mechanism.
Article in Journal of physiology and biochemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Therapeutic potential of spexin in diabetic neuropathy: Insights from in vitro and in vivo models.Experimental physiology · 2026Article
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- Flaxseed (Basic and clinical neuroscience · 2025Article
- Dual Oxytocin Signals in Striatal Astrocytes.Biomolecules · 2025Article
- Peripheral Branch Injury Induces Oxytocin Receptor Expression at the Central Axon Terminals of Primary Sensory Neurons.International journal of molecular sciences · 2023Article
- Inflammatory Orofacial Pain Activates Peptidergic Neurons and Upregulates the Oxytocin Receptor Expression in Trigeminal Ganglion.Biomedicines · 2023Article
- The Comprehensive Neural Mechanism of Oxytocin in Analgesia.Current neuropharmacology · 2022Review
- Article
- Vasopressin and oxytocin in sensory neurones: expression, exocytotic release and regulation by lactation.Scientific reports · 2018Article
- Urinary bladder inflammation induces changes in urothelial nerve growth factor and TRPV1 channels.British journal of pharmacology · 2015Article
- Oxytocin - a multifunctional analgesic for chronic deep tissue pain.Current pharmaceutical design · 2015Review
- Oxytocin reduces cocaine seeking and reverses chronic cocaine-induced changes in glutamate receptor function.The international journal of neuropsychopharmacology · 2014Article
- Epigenetic modification of DRG neuronal gene expression subsequent to nerve injury: etiological contribution to complex regional pain syndromes (Part II).Medical science monitor : international medical journal of experimental and clinical research · 2014Review
- Oxytocin inhibits the activity of acid-sensing ion channels through the vasopressin, V1A receptor in primary sensory neurons.British journal of pharmacology · 2014Article
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In addition to its well-known effects on parturition and lactation, oxytocin (OT) plays an important role in modulation of pain and nociceptive transmission. But, the mechanism of this effect is unclear. To address the possible role of OT on pain modulation at the peripheral level, the effects of OT on intracellular calcium levels ([Ca(2+)](i)) in rat dorsal root ganglion (DRG) neurons were investigated by using an in vitro calcium imaging system. DRG neurons were grown in primary culture following enzymatic and mechanical dissociation of ganglia from 1- or 2-day-old neonatal Wistar rats. Using the fura-2-based calcium imaging technique, the effects of OT on [Ca(2+)](i) and role of the protein kinase C (PKC)-mediated pathway in OT effect were assessed. OT caused a significant increase in basal levels of [Ca(2+)](i) after application at the doses of 30 nM (n = 34, p < 0.01), 100 nM (n = 41, p < 0.001) and 300 nM (n = 46, p < 0.001). The stimulatory effect of OT (300 nM) on [Ca(2+)](i) was persistent in Ca(2+)-free conditions (n = 56, p < 0.01). Chelerythrine chloride, a PKC inhibitor, significantly reduced the OT-induced increase in [Ca(2+)](i) (n = 28, p < 0.001). We demonstrated that OT activates intracellular calcium signaling in cultured rat primary sensory neurons in a dose- and PKC-dependent mechanism. The finding of the role of OT in peripheral pain modification may serve as a novel target for the development of new pharmacological strategies for the management of pain.
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