Evidence map›Paper›PMID 23912681›Full record

ArticleSocial cognitive and affective neuroscience2014

Default mode network connectivity and reciprocal social behavior in 22q11.2 deletion syndrome.

Matthew J Schreiner, Katherine H Karlsgodt, Lucina Q Uddin, Carolyn Chow, Eliza Congdon, Maria Jalbrzikowski, Carrie E Bearden

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Social cognitive and affective neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 79 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Matthew J SchreinerInterdepartmental Neuroscience Program, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, Department of Psychiatry, Feinstein Institute for Medical Research, Manhasset, NY 11030, Zucker Hillside Hospital, Glen Oaks, NY 11004, Department of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 and Department of Psychology, University of California, Los Angeles, CA 90095, USA Interdepartmental Neuroscience Program, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, Department of Psychiatry, Feinstein Institute for Medical Research, Manhasset, NY 11030, Zucker Hillside Hospital, Glen Oaks, NY 11004, Department of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 and Department of Psychology, University of California, Los Angeles, CA 90095, USA.
Katherine H KarlsgodtInterdepartmental Neuroscience Program, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, Department of Psychiatry, Feinstein Institute for Medical Research, Manhasset, NY 11030, Zucker Hillside Hospital, Glen Oaks, NY 11004, Department of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 and Department of Psychology, University of California, Los Angeles, CA 90095, USA Interdepartmental Neuroscience Program, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, Department of Psychiatry, Feinstein Institute for Medical Research, Manhasset, NY 11030, Zucker Hillside Hospital, Glen Oaks, NY 11004, Department of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 and Department of Psychology, University of California, Los Angeles, CA 90095, USA.
Lucina Q UddinInterdepartmental Neuroscience Program, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, Department of Psychiatry, Feinstein Institute for Medical Research, Manhasset, NY 11030, Zucker Hillside Hospital, Glen Oaks, NY 11004, Department of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 and Department of Psychology, University of California, Los Angeles, CA 90095, USA.
Carolyn ChowInterdepartmental Neuroscience Program, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, Department of Psychiatry, Feinstein Institute for Medical Research, Manhasset, NY 11030, Zucker Hillside Hospital, Glen Oaks, NY 11004, Department of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 and Department of Psychology, University of California, Los Angeles, CA 90095, USA.
Eliza CongdonInterdepartmental Neuroscience Program, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, Department of Psychiatry, Feinstein Institute for Medical Research, Manhasset, NY 11030, Zucker Hillside Hospital, Glen Oaks, NY 11004, Department of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 and Department of Psychology, University of California, Los Angeles, CA 90095, USA.
Maria JalbrzikowskiInterdepartmental Neuroscience Program, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, Department of Psychiatry, Feinstein Institute for Medical Research, Manhasset, NY 11030, Zucker Hillside Hospital, Glen Oaks, NY 11004, Department of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 and Department of Psychology, University of California, Los Angeles, CA 90095, USA Interdepartmental Neuroscience Program, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, Department of Psychiatry, Feinstein Institute for Medical Research, Manhasset, NY 11030, Zucker Hillside Hospital, Glen Oaks, NY 11004, Department of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 and Department of Psychology, University of California, Los Angeles, CA 90095, USA.
Carrie E BeardenInterdepartmental Neuroscience Program, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, Department of Psychiatry, Feinstein Institute for Medical Research, Manhasset, NY 11030, Zucker Hillside Hospital, Glen Oaks, NY 11004, Department of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 and Department of Psychology, University of California, Los Angeles, CA 90095, USA Interdepartmental Neuroscience Program, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, Department of Psychiatry, Feinstein Institute for Medical Research, Manhasset, NY 11030, Zucker Hillside Hospital, Glen Oaks, NY 11004, Department of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 and Department of Psychology, University of California, Los Angeles, CA 90095, USA cbearden@mednet.ucla.edu.
Neurosciences Institute · USUniversity of California, Los Angeles · USFeinstein Institute for Medical Research · USStanford University · USZucker Hillside Hospital · US

Funding

Understanding Repetitive Behavior in AutismP50HD055784 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GESCHWIND, DANIEL H · 2007 to 2021
$32.0M
Neurodevelopment and Psychosis in the 22q11.2 Deletion SyndromeR01MH085953 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E · 2010 to 2020
$6.2M
Human Translational Applications Core (HTA - Core) (7 of 8)PL1MH083271 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BILDER, ROBERT M · 2007 to 2011
$5.8M
Consortium for Neuropsychiatric Phenomics-Coordinating Center (1 of 8)UL1DE019580 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BILDER, ROBERT M · 2008 to 2011
$1.9M
Response Inhibition and Dopamine Neurotransmission (RI) (4 of 8)RL1DA024853 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LONDON, EDYTHE DANICK · 2007 to 2011
$1.7M
Comprehensive Training in Neuroimaging Fundamentals and ApplicationsT90DA022768 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COHEN, MARK STEVEN · 2006 to 2015
$1.5M
Structural and Functional Connectivity of Large-Scale Brain Networks in Autism SpK01MH092288 · NIMH · UNIVERSITY OF MIAMI CORAL GABLES · PI UDDIN, LUCINA QAZI · 2010 to 2014
$785k
NICHD NIH HHS P50 HD055784NICHD NIH HHS P50-HD-055784NIDA NIH HHS RL1 DA024853NIDA NIH HHS T32T90DA022768NIDA NIH HHS T90 DA022768NIDCR NIH HHS UL1 DE019580NIDCR NIH HHS UL1-DE019580NIMH NIH HHS K01 MH092288NIMH NIH HHS K01MH092288NIMH NIH HHS PL1 MH083271NIMH NIH HHS PL1MH083271NIMH NIH HHS R01 MH085953
6 · The paper itself

Abstract

22q11.2 deletion syndrome (22q11DS) is a genetic mutation associated with disorders of cortical connectivity and social dysfunction. However, little is known about the functional connectivity (FC) of the resting brain in 22q11DS and its relationship with social behavior. A seed-based analysis of resting-state functional magnetic resonance imaging data was used to investigate FC associated with the posterior cingulate cortex (PCC), in (26) youth with 22qDS and (51) demographically matched controls. Subsequently, the relationship between PCC connectivity and Social Responsiveness Scale (SRS) scores was examined in 22q11DS participants. Relative to 22q11DS participants, controls showed significantly stronger FC between the PCC and other default mode network (DMN) nodes, including the precuneus, precentral gyrus and left frontal pole. 22q11DS patients did not show age-associated FC changes observed in typically developing controls. Increased connectivity between PCC, medial prefrontal regions and the anterior cingulate cortex, was associated with lower SRS scores (i.e. improved social competence) in 22q11DS. DMN integrity may play a key role in social information processing. We observed disrupted DMN connectivity in 22q11DS, paralleling reports from idiopathic autism and schizophrenia. Increased strength of long-range DMN connectivity was associated with improved social functioning in 22q11DS. These findings support a 'developmental-disconnection' hypothesis of symptom development in this disorder.

Indexed as

Social BehaviorAdolescentAdultCase-Control StudiesChildDiGeorge SyndromeFemaleGyrus CinguliHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleNeural PathwaysNeuropsychological TestsOxygenYoung AdultOxygendysconnectivityfunctional MRIresting statevelocardiofacial syndrome

Identifiers

PMID23912681
PMCPMC4158365
OpenAlexW2143441580

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.