ArticleThe journal of physiological sciences : JPS2013
Ace I/D polymorphism is associated with habitual physical activity in pubertal boys.
Article in The journal of physiological sciences : JPS, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Genetic variants related to physical activity or sedentary behaviour: a systematic review.The international journal of behavioral nutrition and physical activity · 2021Pooled it
- Distribution of allele frequencies for genes associated with physical activity and/or physical capacity in a homogenous Norwegian cohort- a cross-sectional study.BMC genetics · 2020Article
- Alleles associated with physical activity levels are estimated to be older than anatomically modern humans.PloS one · 2019Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the association between the angiotensin I-converting enzyme (ACE) gene insertion (I)/deletion (D) polymorphism and physical activity levels in boys at early pubertal stage (calendar age 12.04 ± 0.77 years). Body composition by DXA, pubertal stage and cardiovascular fitness on cycle ergometer were measured in addition to 7-day accelerometry. DNA was separated from the whole blood. Sedentary behaviour level was significantly lower in DD subjects compared to I allele carriers. A significant main effect of the D allele was found on total physical activity (F 1,256 = 5,453; p = 0.020; η (2) = 0.021] and on light physical activity (F 1,256 = 4.74; p = 0.030; η (2) = 0.018). Adding screen time as a covariate did not change ACE I/D polymorphism effect on total physical activity levels (F 2,256 = 3,326; p = 0.041; η (2) = 0.025). Carriers of the D allele had significantly higher light physical activity (F 1,256 = 4,710; p = 0.031; η (2) = 0.20), with screen time as covariate. In conclusion, ACE gene has a significant effect on sedentary, light and total physical activity levels in healthy 12-year-old boys.
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