Evidence map›Paper›PMID 23912310›Full record

ReviewAsian journal of andrology2013

The effects of advanced paternal age on fertility.

Jason R Kovac, Josephine Addai, Ryan P Smith, Robert M Coward, Dolores J Lamb, Larry I Lipshultz

Abstract readReview
In one paragraph

Review in Asian journal of andrology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Oxidative Stress and Male Reproductive Health-First Edition.Antioxidants (Basel, Switzerland) · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Male aging in germ cells: What are we inheriting?Genetics and molecular biology · 2025
    Article
  11. Physician infertility: a structured literature review.Journal of assisted reproduction and genetics · 2024
    Review
  12. Inhibition ofCells · 2024
    Article
  13. Age-Related COVID-19 Influence on Male Fertility.International journal of molecular sciences · 2023
    Article
  14. Article
  15. Review
  16. Article
  17. Male factor testing in recurrent pregnancy loss cases: A narrative review.International journal of reproductive biomedicine · 2022
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jason R Kovac
Josephine Addai
Ryan P Smith
Robert M Coward
Dolores J Lamb
Larry I Lipshultz

Funding

ZONA PELLUCIDA BINDING PROTEINS IN SPERM-EGG INTERACTIONSP01HD036289 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MATZUK, MARTIN M. · 2000 to 2010
$7.5M
Improving the Diagnosis of Congenital Genitourinary Defects.R01DK078121 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI LAMB, DOLORES JEAN · 2007 to 2021
$4.8M
K-12: Male Reproductive Health Research (MRHR) Career Development Program at BCMK12HD073917 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI LAMB, DOLORES JEAN · 2012 to 2016
$1.7M
NICHD NIH HHS K12 HD073917NICHD NIH HHS K12 HD073917-01NICHD NIH HHS P01 HD036289NICHD NIH HHS P01HD36289NIDDK NIH HHS 1R01DK078121NIDDK NIH HHS R01 DK078121
6 · The paper itself

Abstract

Modern societal pressures and expectations over the past several decades have resulted in the tendency for couples to delay conception. While women experience a notable decrease in oocyte production in their late thirties, the effect of age on spermatogenesis is less well described. While there are no known limits to the age at which men can father children, the effects of advanced paternal age are incompletely understood. This review summarizes the current state of knowledge regarding advanced paternal age and its implications on semen quality, reproductive success and offspring health. This review will serve as a guide to physicians in counseling men about the decision to delay paternity and the risks involved with conception later in life.

Indexed as

FertilityPaternal AgeAdultAgingHumansMaleMiddle Aged

Identifiers

PMID23912310
PMCPMC3854059

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.