ArticleNature cell biology2013
Wg and Wnt4 provide long-range directional input to planar cell polarity orientation in Drosophila.
Article in Nature cell biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.
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Who cites it
105 citing papers in PubMed.
- Epithelial-mesenchymal Wnt crosstalk directs planar cell polarity in the developing cochlea.Nature communications · 2026Article
- Modeling Complex Developmental Disease: The Case of Polycystic Kidney Disease.Journal of developmental biology · 2026Review
- Article
- Epithelial-Mesenchymal Wnt Crosstalk Directs Planar Cell Polarity in the Developing Cochlea.bioRxiv : the preprint server for biology · 2026Article
- Planar cell polarity emerges through polarized accumulation of Wnt11.Science advances · 2026Article
- Start small: A model for tissue-wide planar cell polarity without morphogens.PLoS computational biology · 2026Article
- Spatial fibroblast niches define Crohn's fistulae.Nature · 2026Article
- Linking Planar Cell Polarity to Mechanotransduction During Morphogenesis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Article
- Planar cell polarity coordination in a cnidarian embryo provides clues to animal body axis evolution.eLife · 2025Article
- Tissue shear as a cue for aligning planar polarity in the developing Drosophila wing.Nature communications · 2025Article
- Structural basis of human VANGL-PRICKLE interaction.Nature communications · 2025Article
- Review
- Article
- Review
- The interplay between Wnt signaling pathways and microtubule dynamics.In vitro cellular & developmental biology. Animal · 2024Review
- Planar Cell Polarity Signaling: Coordinated Crosstalk for Cell Orientation.Journal of developmental biology · 2024Review
- TheFrontiers in synaptic neuroscience · 2024Article
- Vangl-dependent Wnt/planar cell polarity signaling mediates collective breast carcinoma motility and distant metastasis.Breast cancer research : BCR · 2023Article
- Wnt4 and ephrinB2 instruct apical constriction via Dishevelled and non-canonical signaling.Nature communications · 2023Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Planar cell polarity (PCP) is cellular polarity within the plane of an epithelial tissue or organ. PCP is established through interactions of the core Frizzled (Fz)/PCP factors and, although their molecular interactions are beginning to be understood, the upstream input providing the directional bias and polarity axis remains unknown. Among core PCP genes, Fz is unique as it regulates PCP both cell-autonomously and non-autonomously, with its extracellular domain acting as a ligand for Van Gogh (Vang). We demonstrate in Drosophila melanogaster wings that Wg (Wingless) and dWnt4 (Drosophila Wnt homologue) provide instructive regulatory input for PCP axis determination, establishing polarity axes along their graded distribution and perpendicular to their expression domain borders. Loss-of-function studies reveal that Wg and dWnt4 act redundantly in PCP determination. They affect PCP by modulating the intercellular interaction between Fz and Vang, which is thought to be a key step in setting up initial polarity, thus providing directionality to the PCP process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.