ArticleNature nanotechnology2013
Tracking the engraftment and regenerative capabilities of transplanted lung stem cells using fluorescent nanodiamonds.
Article in Nature nanotechnology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
74 citing papers in PubMed, 260 citations in OpenAlex.
- Improving the creation of SiV centers in diamond via sub-μs pulsed annealing treatment.Nature communications · 2024Article
- Review
- Viral airway injury promotes cell engraftment in an in vitro model of cystic fibrosis cell therapy.American journal of physiology. Lung cellular and molecular physiology · 2024Article
- Fluorescence-Based Mono- and Multimodal Imaging for In Vivo Tracking of Mesenchymal Stem Cells.Biomolecules · 2023Review
- Fluorescent Nanodiamonds for Tracking Single Polymer Particles in Cells and Tissues.Analytical chemistry · 2023Article
- Silicon Vacancy in Boron-Doped Nanodiamonds for Optical Temperature Sensing.Materials (Basel, Switzerland) · 2023Article
- Multiple Bioimaging Applications Based on the Excellent Properties of Nanodiamond: A Review.Molecules (Basel, Switzerland) · 2023Review
- Nanomaterial-based contrast agents.Nature reviews. Methods primers · 2023Article
- Optical and MRI Multimodal Tracing of Stem Cells In Vivo.Molecular imaging · 2023Review
- Fluorescence lifetime image microscopy prediction with convolutional neural networks for cell detection and classification in tissues.PNAS nexus · 2022Article
- Use of Magnetic Modulation of Nitrogen-Vacancy Center Fluorescence in Nanodiamonds for Quantitative Analysis of Nanoparticles in Organisms.ACS measurement science au · 2022Article
- Loss of core-fucosylation of SPARC impairs collagen binding and contributes to COPD.Cellular and molecular life sciences : CMLS · 2022Article
- Synthesis, Characterization, Properties, and Novel Applications of Fluorescent Nanodiamonds.Journal of fluorescence · 2022Review
- Mechanoporation enables rapid and efficient radiolabeling of stem cells for PET imaging.Scientific reports · 2022Article
- Multiplexed sensing of biomolecules with optically detected magnetic resonance of nitrogen-vacancy centers in diamond.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Raman Imaging and Fluorescence Lifetime Imaging Microscopy for Diagnosis of Cancer State and Metabolic Monitoring.Cancers · 2021Review
- Prospect of cell penetrating peptides in stem cell tracking.Stem cell research & therapy · 2021Review
- Quantifying nanodiamonds biodistribution in whole cells with correlative iono-nanoscopy.Nature communications · 2021Article
- Mesenchymal stem/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications.Journal of biomedical science · 2021Review
- The frontier of live tissue imaging across space and time.Cell stem cell · 2021Review
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lung stem/progenitor cells are potentially useful for regenerative therapy, for example in repairing damaged or lost lung tissue in patients. Several optical imaging methods and probes have been used to track how stem cells incorporate and regenerate themselves in vivo over time. However, these approaches are limited by photobleaching, toxicity and interference from background tissue autofluorescence. Here we show that fluorescent nanodiamonds, in combination with fluorescence-activated cell sorting, fluorescence lifetime imaging microscopy and immunostaining, can identify transplanted CD45(-)CD54(+)CD157(+) lung stem/progenitor cells in vivo, and track their engraftment and regenerative capabilities with single-cell resolution. Fluorescent nanodiamond labelling did not eliminate the cells' properties of self-renewal and differentiation into type I and type II pneumocytes. Time-gated fluorescence imaging of tissue sections of naphthalene-injured mice indicates that the fluorescent nanodiamond-labelled lung stem/progenitor cells preferentially reside at terminal bronchioles of the lungs for 7 days after intravenous transplantation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.