ArticleThe Journal of infectious diseases2013
Staphylococcus aureus lipoteichoic acid inhibits platelet activation and thrombus formation via the Paf receptor.
Article in The Journal of infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Bacterial interactions with platelets: defining key themes.Frontiers in immunology · 2025Review
- The role of platelets in sepsis: A review.Biomolecules & biomedicine · 2024Review
- Activation of Human Platelets byPathogens (Basel, Switzerland) · 2022Article
- Review
- Aspirin and Infection: A Narrative Review.Biomedicines · 2022Review
- Platelets in pediatric and neonatal sepsis: novel mediators of the inflammatory cascade.Pediatric research · 2022Review
- Platelet Innate Immune Receptors and TLRs: A Double-Edged Sword.International journal of molecular sciences · 2021Review
- Transfer to the clinic: refining forward programming of hPSCs to megakaryocytes for platelet production in bioreactors.Blood advances · 2021Article
- A Champion of Host Defense: A Generic Large-Scale Cause for Platelet Dysfunction and Depletion in Infection.Seminars in thrombosis and hemostasis · 2020Review
- Crosstalk Between Platelets and Microbial Pathogens.Frontiers in immunology · 2020Review
- Patrolling the vascular borders: platelets in immunity to infection and cancer.Nature reviews. Immunology · 2019Review
- Acetylsalicylic acid differentially limits the activation and expression of cell death markers in human platelets exposed to Staphylococcus aureus strains.Scientific reports · 2017Article
- Coordinated Molecular Cross-Talk between Staphylococcus aureus, Endothelial Cells and Platelets in Bloodstream Infection.Pathogens (Basel, Switzerland) · 2015Review
- Bacterial exploitation of phosphorylcholine mimicry suppresses inflammation to promote airway infection.The Journal of clinical investigation · 2015Article
- Platelets and infections - complex interactions with bacteria.Frontiers in immunology · 2015Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Impaired healing is common in wounds infected with the major human pathogen Staphylococcus aureus, although the underlying mechanisms are poorly understood. Here, we show that S. aureus lipoteichoic acid (LTA) inhibits platelet aggregation caused by physiological agonists and S. aureus and reduced platelet thrombus formation in vitro. The presence of D-alanine on LTA is necessary for the full inhibitory effect. Inhibition of aggregation was blocked using a monoclonal anti-platelet activating factor receptor (PafR) antibody and Ginkgolide B, a well-defined PafR antagonist, demonstrating that the LTA inhibitory signal occurs via PafR. Using a cyclic AMP (cAMP) assay and a Western blot for phosphorylated VASP, we determined that cAMP levels increase upon platelet incubation with LTA, an effect which inhibits platelet activation. This was blocked when platelets were preincubated with Ginkgolide B. Furthermore, LTA reduced hemostasis in a mouse tail-bleed assay.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.