Observational studyThe Journal of infectious diseases2013
Changes in measles serostatus among HIV-infected Zambian children initiating antiretroviral therapy before and after the 2010 measles outbreak and supplemental immunization activities.
Observational study in The Journal of infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Timing of antiretroviral treatment initiation and seropositivity to measles virus among children living with HIV in rural Zambia.medRxiv : the preprint server for health sciences · 2026Article
- The delivery of new tuberculosis vaccines to people living with HIV - when to vaccinate?BMC infectious diseases · 2025Article
- Sero-survey of measles virus antibodies among symptomatic children attending Abuja Teaching Hospital, Nigeria.GMS hygiene and infection control · 2021Article
- Seroprevalence of measles vaccine antibody response in vertically HIV-infected children, in Morocco.BMC infectious diseases · 2018Article
- Safety and Immunogenicity of Measles Vaccination in HIV-Infected and HIV-Exposed Uninfected Children: A Systematic Review and Meta-Analysis.EClinicalMedicine · 2018Article
- Measles and Rubella Seroprevalence Among HIV-infected and Uninfected Zambian Youth.The Pediatric infectious disease journal · 2017Article
- Risk Factors for Measles in HIV-infected Children and Adolescents in Botswana.The Pediatric infectious disease journal · 2015Article
- Spatial clustering of measles cases during endemic (1998-2002) and epidemic (2010) periods in Lusaka, Zambia.BMC infectious diseases · 2015Article
- Changes in cellular immune activation and memory T-cell subsets in HIV-infected Zambian children receiving HAART.Journal of acquired immune deficiency syndromes (1999) · 2014Observational
- Antiretroviral therapy restores age-dependent loss of resting memory B cells in young HIV-infected Zambian children.Journal of acquired immune deficiency syndromes (1999) · 2014Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundIn 2010, Zambia had a large measles outbreak, providing an opportunity to measure changes in measles serostatus following highly active antiretroviral therapy (HAART), exposure to measles virus, and revaccination among children infected with human immunodeficiency virus (HIV).
methodsA prospective cohort study of 169 HIV-infected Zambian children aged 9-60 months with a history of measles vaccination was conducted to characterize the effects of HAART and revaccination on measles immunoglobulin G (IgG) serostatus by enzyme immunoassay.
resultsPrior to the measles outbreak, only 23% of HIV-infected children were measles IgG seropositive at HAART initiation. After adjusting for 6-month changes in baseline age and 5% changes in nadir CD4(+) T-cell percentage, HAART was not associated with measles IgG seroconversion. However, 18 of 19 children seroconverted after revaccination. Eight children seroconverted during the outbreak without revaccination and were likely exposed to wild-type measles virus, but none were reported to have had clinical measles.
conclusionsImmune reconstitution after HAART initiation did not restore protective levels of measles IgG antibodies, but almost all children developed protective antibody levels after revaccination. Some previously vaccinated HIV-infected children had serological evidence of exposure to wild-type measles virus without a reported history of measles.
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