Trial reportJournal of diabetes science and technology2013
Noninvasive skin fluorescence spectroscopy is comparable to hemoglobin A1c and fasting plasma glucose for detection of abnormal glucose tolerance.
Trial report in Journal of diabetes science and technology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Caffeine Consumption Contributes to Skin Intrinsic Fluorescence in Type 1 Diabetes.Diabetes technology & therapeutics · 2015Trial
- Weak Association between Skin Autofluorescence Levels and Prediabetes with an ILERVAS Cross-Sectional Study.Nutrients · 2022Article
- Skin Intrinsic Fluorescence and Age-Related Macular Degeneration: The Beaver Dam Eye Study.Investigative ophthalmology & visual science · 2017Article
- Association of Skin Intrinsic Fluorescence with Retinal Microvascular Complications of Long Term Type 1 Diabetes in the Wisconsin Epidemiologic Study of Diabetic Retinopathy.Ophthalmic epidemiology · 2017Article
- Status Update on Translation of Integrated Primary Dental-Medical Care Delivery for Management of Diabetic Patients.Clinical medicine & research · 2017Review
- Skin fluorescence as a clinical tool for non-invasive assessment of advanced glycation and long-term complications of diabetes.Glycoconjugate journal · 2016Review
- Epidemiology of Dysglycemia in Pregnant Oklahoma American Indian Women.The Journal of clinical endocrinology and metabolism · 2015Article
- Emerging trends in optical sensing of glycemic markers for diabetes monitoring.Trends in analytical chemistry : TRAC · 2015Article
- Noninvasive skin fluorescence spectroscopy for diabetes screening.Journal of diabetes science and technology · 2013Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimWe compare performance of noninvasive skin fluorescence spectroscopy (SFS), fasting plasma glucose (FPG), and hemoglobin A1c (A1C) for detection of abnormal glucose tolerance (AGT).
methodsThe NSEEDS trial evaluated SFS, FPG, and A1C in an at-risk population of 479 previously undiagnosed subjects from nine US centers, each of whom received a 75 g, 2 h oral glucose tolerance test (OGTT). Skin fluorescence spectra were collected and analyzed with SCOUT DS® devices. Disease truth was AGT, defined as OGTT ≥140 mg/dl. Abnormal glucose tolerance sensitivity, false positive rate (FPR), and receiver operating characteristic (ROC) curves were computed for each measurement technique. Skin fluorescence spectroscopy reproducibility was also assessed.
resultsThe AGT sensitivity of SFS was 68.2%, higher than that of FPG (thresholds of 100 and 110 mg/dl) and A1C (thresholds of 5.7% and 6.0%). The FPR of SFS was 37.7%, comparable to A1C at the 5.7% threshold (30.7%). Partial ROC areas of SFS, FPG, and A1C were similar for FPRs of 20-50% (average sensitivities of 64.0%, 59.0%, and 68.6%, respectively). The interday coefficient of variation for SFS was 7.6%.
conclusionsSkin fluorescence spectroscopy has similar screening performance to FPG and A1C and is a viable approach for detection of AGT.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.