Evidence map›Paper›PMID 23910433›Full record

ReviewLancet (London, England)2014

Adult obstructive sleep apnoea.

Amy S Jordan, David G McSharry, Atul Malhotra

5 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Lancet (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 880 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
880citing papers in PubMed, 17 pooled it
34.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03109171 narecruitingnot on this mapstarted 2018, after this paper: background citation

Accuracy of the Sensory Test Performed Using the Laryngopharyngeal Endoscopic Esthesiometer and Rangefinder in Patients With Suspected Obstructive Sleep Apnoea Hypopnea (OSA): a Prospective Double-blinded, Randomised, Pilot Study

TypeinterventionalSponsorFundación Neumologica ColombianaRan2018 to 2026Enrolled117ConditionsSleep Apnea, Obstructive, Larynx, Sensory DisorderArmsLaryngopharyngeal sensory test
NCT03930875 completednot on this mapstarted 2017, after this paper: background citation

Aspirin Resistance in Obstructive Sleep Apnea Patients (ARISA Trial)

TypeobservationalSponsorDanbury HospitalRan2017 to 2018Enrolled63ConditionsObstructive Sleep ApneaArmsAspirin Resistance testing
NCT04323254 unknown statusnot on this mapstarted 2020, after this paper: background citation

The Language of Sleepiness

TypeobservationalSponsorUniversity of California, San DiegoRan2020 to 2021Enrolled200ConditionsSleep, Sleep Disorder, Sleepiness
NCT05549245 naunknown statusnot on this mapstarted 2022, after this paper: background citation

RCT Study of Short-term Clinical Efficacy of High Flow Nasal Catheter Oxygen Therapy for Obstructive Sleep Apnea

TypeinterventionalSponsorQilu Hospital of Shandong UniversityRan2022 to 2023Enrolled194ConditionsObstructive Sleep ApneaArmshigh-flow nasal cannula oxygen therapy,, CPAP
NCT05549310 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Long-term Effect of High Flow Nasal Canula Therapy on Obstructive Sleep Apnea

TypeinterventionalSponsorQilu Hospital of Shandong UniversityRan2022 to 2025Enrolled186ConditionsObstructive Sleep Apnea, High Flow Nasal Canula, Continuous Positive Airway Pressure VentilationArmsCPAP, high-flow nasal canula oxygen therapy
3 · Its place in the literature

Who cites it

880 citing papers in PubMed, 17 syntheses or guidelines pooled it, 1,603 citations in OpenAlex.

  1. Oral appliances for obstructive sleep apnoea in adults.The Cochrane database of systematic reviews · 2026
    Pooled it
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  5. Adverse Airway Events Following Head and Neck Cancer Reconstruction Without Elective Tracheostomy.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026
    Pooled it
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  8. Guideline
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  13. Systematic review of changes in extracellular vesicles associated with obstructive sleep apnoea: implications for diagnosis and treatment.European respiratory review : an official journal of the European Respiratory Society · 2025
    Pooled it
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  15. The effect of continuous positive airway pressure therapy on intraocular pressure in patients with OSA: a systematic review and meta-analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Pooled it
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  18. Trial
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820 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

Amy S JordanUniversity of Melbourne, Melbourne, VIC, Australia; Institute for Breathing and Sleep, Melbourne, VIC, Australia. Electronic address: ajordan@unimelb.edu.au.
David G McSharryBrigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Letterkenny General Hospital, County Donegal, Ireland.
Atul MalhotraBrigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; University of California, San Diego, CA, USA.
Harvard University · USInstitute for Breathing and Sleep · AULetterkenny University Hospital · IE

Funding

Single Motor Unit Genioglossus Recordings to Understand Sleep Apnea PathogenesisR01HL085188 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2008 to 2018
$3.5M
Mechanisms Underlying the Aging Predisposition to Obstructive Sleep ApneaR01HL090897 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MALHOTRA, ATUL · 2009 to 2012
$1.8M
Assessment of Upper Airway Mechanics Using Newer EMG TechniquesK24HL093218 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2009 to 2013
$857k
NHLBI NIH HHS K24 HL093218NHLBI NIH HHS R01 HL085188NHLBI NIH HHS R01 HL090897
6 · The paper itself

Abstract

Obstructive sleep apnoea is an increasingly common disorder of repeated upper airway collapse during sleep, leading to oxygen desaturation and disrupted sleep. Features include snoring, witnessed apnoeas, and sleepiness. Pathogenesis varies; predisposing factors include small upper airway lumen, unstable respiratory control, low arousal threshold, small lung volume, and dysfunctional upper airway dilator muscles. Risk factors include obesity, male sex, age, menopause, fluid retention, adenotonsillar hypertrophy, and smoking. Obstructive sleep apnoea causes sleepiness, road traffic accidents, and probably systemic hypertension. It has also been linked to myocardial infarction, congestive heart failure, stroke, and diabetes mellitus though not definitively. Continuous positive airway pressure is the treatment of choice, with adherence of 60-70%. Bi-level positive airway pressure or adaptive servo-ventilation can be used for patients who are intolerant to continuous positive airway pressure. Other treatments include dental devices, surgery, and weight loss.

Indexed as

Continuous Positive Airway PressurePolysomnographySleep Apnea, ObstructiveWeight LossAccidents, TrafficAdenoidsAdultAge FactorsFemaleHumansHypertensionHypertrophyMaleMenopauseObesityPalatine Tonsil

Identifiers

PMID23910433
PMCPMC3909558
OpenAlexW2032617616

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.