Evidence map›Paper›PMID 23910415›Full record

ReviewMayo Clinic proceedings2013

Materials science and tissue engineering: repairing the heart.

Milica Radisic, Karen L Christman

Open access · greenAbstract readReview
In one paragraph

Review in Mayo Clinic proceedings, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 106 citations in OpenAlex.

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  18. Engineered biomaterials for heart disease.Current opinion in biotechnology · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Milica RadisicInstitute of Biomaterials and Biomedical Engineering and the Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, Canada. Electronic address: m.radisic@utoronto.ca.
Karen L Christman
La Jolla Bioengineering Institute · USUniversity of Toronto · CA

Funding

Extracellular matrix hydrogels for treating ischemiaR01HL113468 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHRISTMAN, KAREN L · 2012 to 2020
$3.1M
CIHR 385981-10NHLBI NIH HHS R01 HL113468
6 · The paper itself

Abstract

Heart failure after a myocardial infarction continues to be a leading killer in the Western world. Currently, there are no therapies that effectively prevent or reverse the cardiac damage and negative left ventricular remodeling process that follows a myocardial infarction. Because the heart has limited regenerative capacity, there has been considerable effort to develop new therapies that could repair and regenerate the myocardium. Although cell transplantation alone was initially studied, more recently, tissue engineering strategies using biomaterial scaffolds have been explored. In this review, we cover the different approaches to engineering the myocardium, including cardiac patches, which are in vitro-engineered constructs of functional myocardium, and injectable scaffolds, which can either encourage endogenous repair and regeneration or act as vehicles to support the delivery of cells and other therapeutics.

Indexed as

Myocytes, CardiacRegenerationTissue EngineeringAnimalsClinical Trials as TopicHeart FailureHumansMyocardial InfarctionPluripotent Stem CellsTissue ScaffoldsVentricular Remodelingbasic fibroblast growth factorbFGFECMEHTembryonic stem cellengineered heart tissueESCextracellular matrixHAhESChuman embryonic stem cellhyaluronic acidinduced pluripotent stem celliPSCleft ventricularLVMeHAmethacrylated hyaluronic acidMImyocardial infarctionpluripotent stem cellsPSCvascular endothelial growth factorVEGF

Identifiers

PMID23910415
PMCPMC3786696
OpenAlexW2051493710

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.