ArticleCell stem cell2013
Regional localization within the bone marrow influences the functional capacity of human HSCs.
Article in Cell stem cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
64 citing papers in PubMed.
- Engineering bone marrow in a dish-a bloody business: preclinical opportunities, translational use cases, and a call for consensus.Journal of thrombosis and haemostasis : JTH · 2026Review
- Bone marrow niches for hematopoietic stem cells.HemaSphere · 2024Review
- Preliminary delivery efficiency prediction of nanotherapeutics into crucial cell populations in bone marrow niche.Asian journal of pharmaceutical sciences · 2023Article
- Immune System Influence on Hematopoietic Stem Cells and Leukemia Development.Advances in experimental medicine and biology · 2023Article
- Exercise to Mend Aged-tissue Crosstalk in Bone Targeting Osteoporosis & Osteoarthritis.Seminars in cell & developmental biology · 2022Review
- The extracellular matrix of hematopoietic stem cell niches.Advanced drug delivery reviews · 2022Review
- Niche-directed therapy in acute myeloid leukemia: optimization of stem cell competition for niche occupancy.Leukemia & lymphoma · 2022Review
- Hematopoietic progenitors polarize in contact with bone marrow stromal cells in response to SDF1.The Journal of cell biology · 2021Article
- Review
- Improved hematopoietic stem cell transplantation upon inhibition of natural killer cell-derived interferon-gamma.Stem cell reports · 2021Article
- The Impact of Sedentary Lifestyle, High-fat Diet, Tobacco Smoke, and Alcohol Intake on the Hematopoietic Stem Cell Niches.HemaSphere · 2021Review
- The Role of Hypoxic Bone Marrow Microenvironment in Acute Myeloid Leukemia and Future Therapeutic Opportunities.International journal of molecular sciences · 2021Review
- Cell Sources for Human In vitro Bone Models.Current osteoporosis reports · 2021Review
- Harnessing Mesenchymal Stromal Cells for the Engineering of Human Hematopoietic Niches.Frontiers in immunology · 2021Review
- Dynamic Changes of the Bone Marrow Niche: Mesenchymal Stromal Cells and Their Progeny During Aging and Leukemia.Frontiers in cell and developmental biology · 2021Review
- The Hematopoietic Bone Marrow Niche Ecosystem.Frontiers in cell and developmental biology · 2021Review
- Manufacturing a Bone Marrow-On-A-Chip Using Maskless Photolithography.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Differences in Steady-State Erythropoiesis in Different Mouse Bones and Postnatal Spleen.Frontiers in cell and developmental biology · 2021Article
- Human hematopoietic microenvironments.PloS one · 2021Article
- Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous studies have shown that the bone marrow (BM) niche plays a key role in mouse hematopoietic stem cell (HSC) function and involves contributions from a broad array of cell types. However, the composition and role of the human BM HSC niche have not been investigated. Here, using human bone biopsy specimens, we provide evidence of HSC propensity to localize to endosteal regions of the trabecular bone area (TBA). Through functional xenograft transplantation, we found that human HSCs localizing to the TBA have superior regenerative and self-renewal capacity and are molecularly distinct from those localizing to the long bone area (LBA). In addition, osteoblasts in the TBA possess unique characteristics and express a key network of factors that regulate TBA- versus LBA-localized human HSCs in vivo. Our study reveals that BM localization and architecture play a critical role in defining the functional and molecular properties of human HSCs.
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.