ArticleJournal of the American Society of Hypertension : JASH
Medication adherence and stroke/TIA risk in treated hypertensives: results from the REGARDS study.
Article in Journal of the American Society of Hypertension : JASH. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Global Burden, Regional Differences, Trends, and Health Consequences of Medication Nonadherence for Hypertension During 2010 to 2020: A Meta-Analysis Involving 27 Million Patients.Journal of the American Heart Association · 2022Pooled it
- Factors associated with stroke among patients with hypertension in Eastern Ethiopia: a case-control study.BMC neurology · 2026Article
- Association Between Caregiver Strain and Self-Care Among Caregivers With Hypertension: Findings From the REGARDS Study.Journal of the American Heart Association · 2024Observational
- Position statement on use of pharmacological combinations in a single pill for treatment of hypertension by Argentine Federation of Cardiology (FAC) and Argentine Society of Hypertension (SAHA).Journal of human hypertension · 2023Review
- Factors and Behaviors Related to Successful Transition of Care After Hospitalization for Ischemic Stroke.Stroke · 2023Observational
- Association Between Caregiver Strain and Self-Care Among Caregivers With Diabetes.JAMA network open · 2021Article
- A Qualitative Study of Barriers and Facilitators to Adherence to Secondary Prevention Medications Among French Patients Suffering from Stroke and Transient Ischemic Attack.Patient preference and adherence · 2020Article
- Article
- Frequency of Medication Non-compliance in Hypertensive Patients Presenting with Stroke: A Case-control Study.Cureus · 2019Article
- A Person-Centered Approach to Poststroke Care: The COMprehensive Post-Acute Stroke Services Model.Journal of the American Geriatrics Society · 2018Article
- Management, prognosis and predictors of unfavourable outcomes in patients newly hospitalized for transient ischemic attack: a real-world investigation from Italy.BMC neurology · 2017Article
- Treatment Intensification for Hypertension in US Ambulatory Medical Care.Journal of the American Heart Association · 2016Article
- Predictors of Uncontrolled Blood Pressure in Treated Hypertensive Individuals: First Population-Based Study in Lebanon.Journal of clinical hypertension (Greenwich, Conn.) · 2016Article
- Treatment of Higher-Risk Patients With an Indication for Revascularization: Evolution Within the Field of Contemporary Percutaneous Coronary Intervention.Circulation · 2016Article
- Poor drug adherence and lack of awareness of hypertension among hypertensive stroke patients in Kampala, Uganda: a cross sectional study.BMC research notes · 2016Article
- Perceived Social Standing, Medication Nonadherence, and Systolic Blood Pressure in the Rural South.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2016Article
- Self-reported Medication Adherence and Adverse Patient Safety Events in CKD.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2015Article
- Coronary heart disease risk factors and outcomes in the twenty-first century: findings from the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study.Current hypertension reports · 2015Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe extent to which low medication adherence in hypertensive individuals contributes to disparities in stroke and transient ischemic attack (TIA) risk is poorly understood.
methodsInvestigators examined the relationship between self-reported medication adherence and blood pressure (BP) control (<140/90 mm Hg), Framingham Stroke Risk Score, and physician-adjudicated stroke/TIA incidence in treated hypertensive subjects (n = 15,071; 51% black; 57% in Stroke Belt) over 4.9 years in the national population-based REGARDS cohort study.
resultsMean systolic BP varied from 130.8 ± 16.2 mm Hg in those reporting high adherence to 137.8 ± 19.5 mm Hg in those reporting low adherence (P for trend < .0001). In logistic regression models, each level of worsening medication adherence was associated with significant and increasing odds of inadequately controlled BP (≥140/90 mm Hg; score = 1, odds ratio [95% confidence interval], 1.20 [1.09-1.30]; score = 2, 1.27 [1.08-1.49]; score = 3 or 4, 2.21 [1.75-2.78]). In hazard models using systolic BP as a mediator, those reporting low medication adherence had 1.08 (1.04-1.14) times greater risk of stroke and 1.08 (1.03-1.12) times greater risk of stroke or TIA.
conclusionLow medication adherence was associated with inadequate BP control and an increased risk of incident stroke or TIA.
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