ArticleAlcoholism, clinical and experimental research2014
Adipose inflammation and macrophage infiltration after binge ethanol and burn injury.
Article in Alcoholism, clinical and experimental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Variation of Pro- and Anti-Inflammatory Factors in Severe Burns: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Immunology and treatments of fatty liver disease.Archives of toxicology · 2025Review
- Gut Microbiota: Target for Modulation of Gut-Liver-Adipose Tissue Axis in Ethanol-Induced Liver Disease.Mediators of inflammation · 2022Review
- A review of the role of ethanol-induced adipose tissue dysfunction in alcohol-associated liver disease.Alcoholism, clinical and experimental research · 2021Review
- Loganin attenuates intestinal injury in severely burned rats by regulating the toll-like receptor 4/NF-κB signaling pathway.Experimental and therapeutic medicine · 2020Article
- Recent advances of sterile inflammation and inter-organ cross-talk in alcoholic liver disease.Experimental & molecular medicine · 2020Review
- Innate Immunity and Alcohol.Journal of clinical medicine · 2019Review
- MyeloidJournal of immunology (Baltimore, Md. : 1950) · 2019Article
- Suppression of the interleukin-1ß-induced inflammatory response of human Chang liver cells by acute and subacute exposure to alcohol: an in vitro study.Croatian medical journal · 2018Article
- Anaphylatoxin Receptors C3aR and C5aR1 Are Important Factors That Influence the Impact of Ethanol on the Adipose Secretome.Frontiers in immunology · 2018Article
- Binge Drinking's Effects on the Body.Alcohol research : current reviews · 2018Review
- Alcohol, Adipose Tissue and Lipid Dysregulation.Biomolecules · 2017Article
- Alcohol exposure differentially effects anti-tumor immunity in females by altering dendritic cell function.Alcohol (Fayetteville, N.Y.) · 2016Article
- Ethanol intoxication prolongs post-burn pulmonary inflammation: role of alveolar macrophages.Journal of leukocyte biology · 2016Article
- Metabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation.Molecular metabolism · 2016Article
- Impaired respiratory function and heightened pulmonary inflammation in episodic binge ethanol intoxication and burn injury.Alcohol (Fayetteville, N.Y.) · 2015Article
- Lipoxin A4 Attenuates Obesity-Induced Adipose Inflammation and Associated Liver and Kidney Disease.Cell metabolism · 2015Article
- Intestine immune homeostasis after alcohol and burn injury.Shock (Augusta, Ga.) · 2015Review
- Alcohol's Burden on Immunity Following Burn, Hemorrhagic Shock, or Traumatic Brain Injury.Alcohol research : current reviews · 2015Review
- Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype.The Journal of biological chemistry · 2014Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundEthanol (EtOH) exposure prior to traumatic injury, such as a burn, elevates systemic and local inflammatory responses and increases morbidity and mortality. Adipose is a large tissue mass that is often inflamed during obesity or other stresses, which disturbs metabolic homeostasis. To date, there has been little investigation into the inflammatory response of adipose tissue after combined EtOH exposure and burn injury.
methodsTwo EtOH exposure regimens were utilized to examine the role of inflammation in adipose tissue after EtOH and burn injury. Mice were either given a single or episodic binge exposure to EtOH or saline followed by scald (burn) or sham injury 30 minutes later. Twenty-four hours post injury, serum and adipose tissue were collected for assessment of inflammatory mediators.
resultsSingle binge EtOH alone induced no inflammation in adipose when compared with sham vehicle-treated mice. However, single binge EtOH followed by burn injury induced significant elevations in mRNA and protein concentrations of pro-inflammatory mediators interleukin-6 (IL-6), KC, and monocyte chemoattractant protein 1 compared with either insult alone or sham vehicle group. Additionally, EtOH exposure and burn injury significantly blunted inducible nitric oxide synthase (iNOS), indicating a complex inflammatory response. Episodic binge EtOH exposure followed by burn injury exacerbated the postburn adipose inflammatory response. The magnitude of the episodic binge-induced inflammatory parameters postburn were 2- to 5-fold greater than the response detected after a single exposure of EtOH, indicating EtOH-induced potentiation of burn-induced inflammatory response. Finally, inflammatory loci and crown-like structures in adipose were significantly increased by episodic binge EtOH and burn injury.
conclusionsThis is the first report of binge and burn-induced crown-like structure formation. Evidence presented herein suggests an important role for alcohol and burn as an additional mediator of adipose inflammation in postburn injury, a common complication in burn patients.
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Registered trials
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