Evidence map›Paper›PMID 23909722›Full record

SynthesisNutrition and cancer2013

Dietary antioxidants and prostate cancer: a review.

Terrence M Vance, Joseph Su, Elizabeth T H Fontham, Sung I Koo, Ock K Chun

Open access · greenAbstract readSystematic Review
In one paragraph

Synthesis in Nutrition and cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.

  1. Dietary polyphenols in prevention and treatment of prostate cancer.International journal of molecular sciences · 2015
    Pooled it
  2. Serum Retinol and Carotenoid Concentrations and Prostate Cancer Risk: Results from the Prostate Cancer Prevention Trial.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2015
    Trial
  3. Article
  4. Review
  5. Oxidative and Antioxidative Biomarker Profiles in Neonatal Hypoxic-Ischemic Encephalopathy: Insights for Pathophysiology and Treatment Strategies.Medical science monitor : international medical journal of experimental and clinical research · 2024
    Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. A Pooled Analysis of 15 Prospective Cohort Studies on the Association between Fruit, Vegetable, and Mature Bean Consumption and Risk of Prostate Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017
    Article
  17. Protective Effect of Green Tea (Evidence-based complementary and alternative medicine : eCAM · 2017
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Terrence M VanceDepartment of Nutritional Sciences, University of Connecticut, Storrs, Connecticut 06269, USA.
Joseph Su
Elizabeth T H Fontham
Sung I Koo
Ock K Chun
University of Connecticut · USLouisiana State University Health Sciences Center New Orleans · USNational Cancer Institute · UA

Funding

Does Dietary Antioxidant Predict Aggressiveness of Prostate Cancer?R03CA159421 · NCI · UNIVERSITY OF CONNECTICUT STORRS · PI CHUN, OCK K. · 2012 to 2013
$155k
NCI NIH HHS 1R03CA159421-01A1NCI NIH HHS R03 CA159421
6 · The paper itself

Abstract

Prostate cancer is the most common noncutaneous cancer in men in the United States. Several studies have examined the relationship between prostate cancer and antioxidants; however, the results of these studies are inconsistent. This article provides a systematic review of studies on prostate cancer and antioxidant intake from diet and supplements. Tea and coffee appear to offer protection against advanced prostate cancer. Different forms of vitamin E appear to exert different effects on prostate cancer, with alpha-tocopherol potentially increasing and gamma-tocopherol potentially decreasing risk of the disease. There is no strong evidence for a beneficial effect of selenium, vitamin C, or beta-carotene, whereas lycopene appears to be negatively associated with risk of the disease. The effect of dietary antioxidants on prostate cancer remains undefined and inconclusive, with different antioxidants affecting prostate cancer risk differentially. Further studies are needed to clarify the relationship between antioxidants and prostate cancer risk and to delineate the underlying mechanisms.

Indexed as

DietDietary Supplementsalpha-TocopherolAntioxidantsAscorbic Acidbeta CaroteneCarotenoidsCoffeegamma-TocopherolHumansLycopeneMalePolyphenolsProstatic NeoplasmsRandomized Controlled Trials as TopicRisk Factorsalpha-TocopherolAntioxidantsAscorbic Acidbeta CaroteneCarotenoidsCoffeegamma-TocopherolLycopenePolyphenolsSeleniumTea

Identifiers

PMID23909722
PMCPMC3823537
OpenAlexW2077280710

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.