ArticleRambam Maimonides medical journal2011
High-altitude illnesses: physiology, risk factors, prevention, and treatment.
Article in Rambam Maimonides medical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.
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The trial behind it
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Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 122 citations in OpenAlex.
- Exploring the gut-exercise link: A systematic review of gastrointestinal disorders in physical activity.World journal of gastroenterology · 2025Pooled it
- Pooled it
- Pooled it
- High-altitude cerebral edema and high-altitude pulmonary edema in a trekker with a decent ascent profile: a case report.Annals of medicine and surgery (2012) · 2026Article
- Climate Change and Sarcopenia: Mechanisms, Vulnerabilities, and Public Health Implications.Calcified tissue international · 2026Review
- Quality and reliability of health information about altitude sickness on Douyin and Bilibili: a cross-sectional study.BMC public health · 2026Article
- Heart rate, blood pressure, and SpOPhysiological reports · 2026Article
- Maternal outcomes at mid-altitudes in anemic pregnant women: Evidence from the WOMAN-2 trial.PloS one · 2026Article
- Utility of PPO-FEV1%pred in predicting postoperative pulmonary complications after secondary surgery in patients with multiple primary lung cancers.Frontiers in oncology · 2026Article
- Olfactory Decline in Elderly at High Altitudes: A Narrative Review.International journal of general medicine · 2026Review
- Plateau Environment, Gut Microbiota, and Depression: A Possible Concealed Connection?Current issues in molecular biology · 2025Review
- Acute mountain sickness prediction: a concerto of multidimensional phenotypic data and machine learning strategies in the framework of predictive, preventive, and personalized medicine.The EPMA journal · 2025Article
- Inulin promotes appetite in mice by regulating the gut microbiota under conditions of rapid entry to the plateau.PloS one · 2025Article
- Risk factors associated with high altitude sickness among travelers: A case control study in Himalaya district of Nepal.PLOS global public health · 2025Article
- Thoracic load carriage impairs the acute physiological response to hypoxia in healthy males.Physiological reports · 2025Article
- Drone-based medical delivery in the extreme conditions of Himalayan region: a feasibility study.BMJ public health · 2024Article
- Sleep Quality Among Pilgrims at High Altitude: A Cross-Sectional Study From Gosaikunda Lake, Nepal (4380 m).Cureus · 2024Article
- Decreased cold-inducible RNA-binding protein (CIRP) binding to GluRl on neuronal membranes mediates memory impairment resulting from prolonged hypobaric hypoxia exposure.CNS neuroscience & therapeutics · 2024Article
- [Effects of Extreme Environments on Human Sleep].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Review
- Load carriage physiology in normoxia and hypoxia.European journal of applied physiology · 2024Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-altitude illnesses encompass the pulmonary and cerebral syndromes that occur in non-acclimatized individuals after rapid ascent to high altitude. The most common syndrome is acute mountain sickness (AMS) which usually begins within a few hours of ascent and typically consists of headache variably accompanied by loss of appetite, nausea, vomiting, disturbed sleep, fatigue, and dizziness. With millions of travelers journeying to high altitudes every year and sleeping above 2,500 m, acute mountain sickness is a wide-spread clinical condition. Risk factors include home elevation, maximum altitude, sleeping altitude, rate of ascent, latitude, age, gender, physical condition, intensity of exercise, pre-acclimatization, genetic make-up, and pre-existing diseases. At higher altitudes, sleep disturbances may become more profound, mental performance is impaired, and weight loss may occur. If ascent is rapid, acetazolamide can reduce the risk of developing AMS, although a number of high-altitude travelers taking acetazolamide will still develop symptoms. Ibuprofen can be effective for headache. Symptoms can be rapidly relieved by descent, and descent is mandatory, if at all possible, for the management of the potentially fatal syndromes of high-altitude pulmonary and cerebral edema. The purpose of this review is to combine a discussion of specific risk factors, prevention, and treatment options with a summary of the basic physiologic responses to the hypoxia of altitude to provide a context for managing high-altitude illnesses and advising the non-acclimatized high-altitude traveler.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.