ArticleFrontiers in synaptic neuroscience2013
Cholinergic modulation of hippocampal network function.
Article in Frontiers in synaptic neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 1 of them a synthesis that pooled it.
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Who cites it
119 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Impact of Endocrine Therapy on Cognitive Functions of Breast Cancer Patients: A Systematic Review.Clinical drug investigation · 2016Pooled it
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- Intrinsic persistent firing in CA1 encodes elapsed time across behaviorally relevant scales.bioRxiv : the preprint server for biology · 2025Article
- Cognitive Impairment in Temporal Lobe Epilepsy: Alterations in the Basal Forebrain Cholinergic System.Brain and behavior · 2025Article
- Cholinergic blockade reveals a role for human hippocampal theta in memory encoding but not retrieval.bioRxiv : the preprint server for biology · 2025Article
- Common Neocortical and Hippocampal Correlates of Performance Errors in a Timing Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
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- Navigating uncertainty: reward location variability induces reorganization of hippocampal spatial representations.bioRxiv : the preprint server for biology · 2025Article
- Acetylcholine in the hippocampus: problems and achievements.Frontiers in neural circuits · 2025Review
- Dampened α7 nAChR activity contributes to audiogenic seizures and hyperactivity in a mouse model of Fragile X Syndrome.bioRxiv : the preprint server for biology · 2024Article
- Community-based reconstruction and simulation of a full-scale model of the rat hippocampus CA1 region.PLoS biology · 2024Article
- Isolated theta waves originating from the midline thalamus trigger memory reactivation during NREM sleep in mice.Nature communications · 2024Article
- Synergistic effects of GFAP and Aβ42: Implications for white matter integrity and verbal memory across the cognitive spectrum.Brain, behavior, & immunity - health · 2024Article
59 more citing papers are in PubMed but not listed here.
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2 authors.
Funding
Abstract
Cholinergic septohippocampal projections from the medial septal area to the hippocampus are proposed to have important roles in cognition by modulating properties of the hippocampal network. However, the precise spatial and temporal profile of acetylcholine release in the hippocampus remains unclear making it difficult to define specific roles for cholinergic transmission in hippocampal dependent behaviors. This is partly due to a lack of tools enabling specific intervention in, and recording of, cholinergic transmission. Here, we review the organization of septohippocampal cholinergic projections and hippocampal acetylcholine receptors as well as the role of cholinergic transmission in modulating cellular excitability, synaptic plasticity, and rhythmic network oscillations. We point to a number of open questions that remain unanswered and discuss the potential for recently developed techniques to provide a radical reappraisal of the function of cholinergic inputs to the hippocampus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.