ArticleFrontiers in behavioral neuroscience2013
Dopaminergic and clinical correlates of pathological gambling in Parkinson's disease: a case report.
Article in Frontiers in behavioral neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Contribution of cognitive and bodily navigation cues to egocentric and allocentric spatial memory in hallucinations due to Parkinson's disease: A case report.Frontiers in behavioral neuroscience · 2022Article
- Caudate nucleus-dependent navigation strategies are associated with increased risk-taking and set-shifting behavior.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Article
- Dopamine receptor mapping with PET imaging in Parkinson's disease.Journal of neurology · 2014Review
- Comparison of the use of screening tools for evaluating cognitive impairment in patients with Parkinson's disease.Dementia & neuropsychologiaArticle
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5 authors.
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Abstract
Dopaminergic medication for motor symptoms in Parkinson's disease (PD) recently has been linked with impulse control disorders, including pathological gambling (PG), which affects up to 8% of patients. PG often is considered a behavioral addiction associated with disinhibition, risky decision-making, and altered striatal dopaminergic neurotransmission. Using [(11)C]raclopride with positron emission tomography, we assessed dopaminergic neurotransmission during Iowa Gambling Task performance. Here we present data from a single patient with PD and concomitant PG. We noted a marked decrease in [(11)C]raclopride binding in the left ventral striatum upon gambling, indicating a gambling-induced dopamine release. The results imply that PG in PD is associated with a high dose of dopaminergic medication, pronounced motor symptomatology, young age at disease onset, high propensity for sensation seeking, and risky decision-making. Overall, the findings are consistent with the hypothesis of medication-related PG in PD and underscore the importance of taking clinical variables, such as age and personality, into account when patients with PD are medicated, to reduce the risk of PG.
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