ArticleCerebral cortex (New York, N.Y. : 1991)2014
Social subordination stress and serotonin transporter polymorphisms: associations with brain white matter tract integrity and behavior in juvenile female macaques.
Article in Cerebral cortex (New York, N.Y. : 1991), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Social Status Shapes Maternal Style Toward Rhesus Macaque Infants in the First Year of Life.Developmental psychobiology · 2026Article
- Effects of Lifelong Low Social Status on Inflammatory Markers in Adult Female Macaques.Biomolecules · 2026Article
- Early life adversity in primates: Behavioral, endocrine, and neural effects.Psychoneuroendocrinology · 2024Article
- The Influence of Life Stress and Sleep Disturbance on White Matter Integrity.Psychiatry investigation · 2023Article
- Effects of social rank and pubertal delay on brain structure in female rhesus macaques.Psychoneuroendocrinology · 2023Article
- Vocal expression of emotional arousal across two call types in young rhesus macaques.Animal behaviour · 2022Article
- Chronic psychosocial stress and experimental pubertal delay affect socioemotional behavior and amygdala functional connectivity in adolescent female rhesus macaques.Psychoneuroendocrinology · 2021Article
- Effects of social subordination and oestradiol on resting-state amygdala functional connectivity in adult female rhesus monkeys.Journal of neuroendocrinology · 2020Article
- Disentangling the effects of early caregiving experience and heritable factors on brain white matter development in rhesus monkeys.NeuroImage · 2019Article
- Differences in how macaques monitor others: Does serotonin play a central role?Wiley interdisciplinary reviews. Cognitive science · 2019Review
- Lifespan Trajectories of White Matter Changes in Rhesus Monkeys.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- A review of nonhuman primate models of early life stress and adolescent drug abuse.Neurobiology of stress · 2018Review
- Persistent alteration in behavioural reactivity to a mild social stressor in rhesus monkeys repeatedly exposed to sevoflurane in infancy.British journal of anaesthesia · 2018Article
- Early impoverished environment delays the maturation of cerebral cortex.Scientific reports · 2018Article
- Maternal buffering beyond glucocorticoids: impact of early life stress on corticolimbic circuits that control infant responses to novelty.Social neuroscience · 2017Article
- Longitudinal assessment of fractional anisotropy alterations caused by simian immunodeficiency virus infection: a preliminary diffusion tensor imaging study.Journal of neurovirology · 2016Article
- Artifact correction in diffusion MRI of non-human primate brains on a clinical 3T scanner.Journal of medical primatology · 2016Article
- In vivo diffusion spectrum imaging of non-human primate brain: initial experience in transcallosal fiber examination.Quantitative imaging in medicine and surgery · 2014Article
- Elevated cerebrospinal fluid 5-hydroxyindoleacetic acid in macaques following early life stress and inverse association with hippocampal volume: preliminary implications for serotonin-related function in mood and anxiety disorders.Frontiers in behavioral neuroscience · 2014Article
- Brain white matter microstructure alterations in adolescent rhesus monkeys exposed to early life stress: associations with high cortisol during infancy.Biology of mood & anxiety disorders · 2013Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
We examined the relationship between social rank and brain white matter (WM) microstructure, and socioemotional behavior, and its modulation by serotonin (5HT) transporter (5HTT) polymorphisms in prepubertal female macaques. Using diffusion tensor imaging and tract-based spatial statistics, social status differences were found in medial prefrontal cortex (mPFC) WM and cortico-thalamic tracts, with subordinates showing higher WM structural integrity (measured as fractional anisotropy, FA) than dominant animals. 5HTT genotype-related differences were detected in the posterior limb of the internal capsule, where s-variants had higher FA than l/l animals. Status by 5HTT interaction effects were found in (1) external capsule (middle longitudinal fasciculus), (2) parietal WM, and (3) short-range PFC tracts, with opposite effects in dominant and subordinate animals. In most regions showing FA differences, opposite differences were detected in radial diffusivity, but none in axial diffusivity, suggesting that differences in tract integrity likely involve differences in myelin. These findings highlight that differences in social rank are associated with differences in WM structural integrity in juveniles, particularly in tracts connecting prefrontal, sensory processing, motor and association regions, sometimes modulated by 5HTT genotype. Differences in these tracts were associated with increased emotional reactivity in subordinates, particularly with higher submissive and fear behaviors.
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