Evidence map›Paper›PMID 23908093›Full record

ArticleChemphyschem : a European journal of chemical physics and physical chemistry2013

Electron cryo-microscopy of TPPS4⋅2HCl tubes reveals a helical organisation explaining the origin of their chirality.

Judith M Short, John A Berriman, Christian Kübel, Zoubir El-Hachemi, Jean-Valère Naubron, Teodor Silviu Balaban

Abstract read
In one paragraph

Article in Chemphyschem : a European journal of chemical physics and physical chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Judith M ShortDivision of Structural Studies, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB1 0QH (UK). jms@mrc-lmb.cam.ac.uk.
John A Berriman
Christian Kübel
Zoubir El-Hachemi
Jean-Valère Naubron
Teodor Silviu Balaban

Funding

Medical Research Council MC_U105184322
6 · The paper itself

Abstract

A widely studied achiral porphyrin, which is highly soluble in aqueous solutions (TPPS4), is shown to self-assemble into helical nanotubes. These were imaged by electron cryo-microscopy and a state-of-the-art image analysis allows building a map at ∼5 Å resolution, one of the highest obtained so far for molecular materials. The authors were able to trace the apparent symmetry breaking to existing nuclei in the "as received samples", while carefully purified samples show that both handnesses occur in equal amounts.

Indexed as

Cryoelectron MicroscopyHydrogen-Ion ConcentrationNanotubesPorphyrinsSolutionsPorphyrinsSolutionstetraphenylporphine sulfonatechiralityelectron cryo‐microscopyhelical reconstructionJ‐aggregates/H‐aggregatesporphyrinoidsself‐assembly

Identifiers

PMID23908093
PMCPMC4281918

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.