Evidence map›Paper›PMID 23908056›Full record

ReviewWormBook : the online review of C. elegans biology2013

TGF-β signaling in C. elegans.

Tina L Gumienny, Cathy Savage-Dunn

Open access · bronzeAbstract readReview
In one paragraph

Review in WormBook : the online review of C. elegans biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 162 citations in OpenAlex.

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  8. Evaluation of ProbioticMicroorganisms · 2025
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  12. Genome-wide analysis of Smad and Schnurri transcription factors inbioRxiv : the preprint server for biology · 2025
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  13. Article
  14. Review
  15. Article
  16. BMP signaling to pharyngeal muscle in theMolecular biology of the cell · 2024
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  17. BMP signaling to pharyngeal muscle in thebioRxiv : the preprint server for biology · 2024
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  18. A Comparative Study of Life History Traits inmicroPublication biology · 2024
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  19. Article
  20. Review

39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Tina L GumiennyDepartment of Molecular and Cellular Medicine, Texas A&M Health Science Center College of Medicine, College Station, TX 77843, USA.
Cathy Savage-Dunn
Texas A&M Health Science Center · US

Funding

Molecular Mechanisms Regulating Intercellular Transit of TGF-betaR01GM097591 · NIGMS · TEXAS WOMAN'S UNIVERSITY · PI GUMIENNY, TINA L · 2011 to 2015
$1.0M
Body size control genes &TGF-beta signaling C. elegansR15GM073678 · NIGMS · QUEENS COLLEGE · PI SAVAGE-DUNN, CATHY · 2005 to 2009
$313k
Genetics of Cell Signaling in C. elegans Growth RegulationR15GM097692 · NIGMS · QUEENS COLLEGE · PI SAVAGE-DUNN, CATHY · 2011 to 2011
$310k
NIGMS NIH HHS 1R01GM097591-01NIGMS NIH HHS 1R15GM073678NIGMS NIH HHS 1R15GM097692NIGMS NIH HHS R01 GM097591NIGMS NIH HHS R15 GM073678NIGMS NIH HHS R15 GM097692
6 · The paper itself

Abstract

Transforming Growth Factor-β (TGF-β) superfamily ligands regulate many aspects of cell identity, function, and survival in multicellular animals. Genes encoding five TGF-β family members are present in the genome of C. elegans. Two of the ligands, DBL-1 and DAF-7, signal through a canonical receptor-Smad signaling pathway; while a third ligand, UNC-129, interacts with a noncanonical signaling pathway. No function has yet been associated with the remaining two ligands. Here we summarize these signaling pathways and their biological functions.

Indexed as

Signal TransductionAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsNeuropeptidesTransforming Growth Factor betaCaenorhabditis elegans ProteinsDAF-7 protein, C elegansDbl-1 protein, C elegansNeuropeptidesTransforming Growth Factor betaUNC-129 protein, C elegans

Identifiers

PMID23908056
PMCPMC5081272
OpenAlexW2007742744

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.