ReviewHeart and vessels2014
Current perspectives in genetic cardiovascular disorders: from basic to clinical aspects.
Review in Heart and vessels, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 49 citations in OpenAlex.
- Beyond Familial Hypercholesterolemia: Your Feet can Help Predict Your Coronary Atherosclerosis.Journal of atherosclerosis and thrombosis · 2026Article
- Reduced Kidney Function and Left Atrial Dilatation as Predictors of Incident Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy.Journal of arrhythmia · 2025Article
- Your Foot Can Help Predict Your Cardiovascular Risk.Journal of atherosclerosis and thrombosis · 2023Article
- Polygenic risk scores for low-density lipoprotein cholesterol and familial hypercholesterolemia.Journal of human genetics · 2021Article
- Model-based clustering of multi-tissue gene expression data.Bioinformatics (Oxford, England) · 2020Article
- Review
- Function and Immunogenicity of Gene-corrected iPSC-derived Hepatocyte-Like Cells in Restoring Low Density Lipoprotein Uptake in Homozygous Familial Hypercholesterolemia.Scientific reports · 2019Article
- Functional analysis of KCNH2 gene mutations of type 2 long QT syndrome in larval zebrafish using microscopy and electrocardiography.Heart and vessels · 2019Article
- Prognostic predictive value of gene mutations in Japanese patients with hypertrophic cardiomyopathy.Heart and vessels · 2017Article
- Prominent QTc prolongation in a patient with a rare variant in the cardiac ryanodine receptor gene.Heart and vessels · 2017Article
- Myocardial triglyceride content in patients with left ventricular hypertrophy: comparison between hypertensive heart disease and hypertrophic cardiomyopathy.Heart and vessels · 2017Observational
- Latent pathogenicity of the G38S polymorphism of KCNE1 KHeart and vessels · 2017Article
- Right coronary cusp as a new window of ablation for pilsicainide-induced ventricular premature contractions in a patient with Brugada syndrome.Heart and vessels · 2016Article
- Short- and long-term inhibition of cardiac inward-rectifier potassium channel current by an antiarrhythmic drug bepridil.Heart and vessels · 2016Article
- Prognostic significance of late gadolinium enhancement quantification in cardiac magnetic resonance imaging of hypertrophic cardiomyopathy with systolic dysfunction.Heart and vessels · 2016Article
- A novel cardiac ryanodine receptor gene (RyR2) mutation in an athlete with aborted sudden cardiac death: a case of adult-onset catecholaminergic polymorphic ventricular tachycardia.Heart and vessels · 2015Article
- Clinical Characteristics and Prognosis of End-stage Hypertrophic Cardiomyopathy.Chinese medical journal · 2015Article
- Lipoprotein metabolism in familial hypercholesterolemia: Serial assessment using a one-step ultracentrifugation method.Practical laboratory medicine · 2015Article
- A low prevalence of sarcomeric gene variants in a Chinese cohort with left ventricular non-compaction.Heart and vessels · 2015Article
- Evaluation of coronary artery disease and cardiac morphology and function in patients with hypertrophic cardiomyopathy, using cardiac computed tomography.Heart and vessels · 2015Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We summarize recent advances in the clinical genetics of hypercholesterolemia, hypertrophic cardiomyopathy (HCM), and lethal arrhythmia, all of which are monogenic cardiovascular diseases being essential to understanding the heart and circulatory pathophysiology. Among the issues of hypercholesterolemia which play a pivotal role in development of vascular damages, familial hypercholesterolemia is the common genetic cardiovascular disease; in addition to identifying the gene mutation coding low-density lipoprotein receptor, lipid kinetics in autosomal recessive hypercholesterolemia as well as in proprotein convertase subtilisin/kexin 9 gene mutation were recently demonstrated. As for HCM, some gene mutations were identified to correlate with clinical manifestations. Additionally, a gene polymorphism of the renin-angiotensin system in development of heart failure was identified as a modifier gene. The lethal arrhythmias such as sudden death syndromes, QT prolongation, and Brugada syndrome were found to exhibit gene mutation coding potassium and/or sodium ion channels. Interestingly, functional analysis of these gene mutations helped to identify the role of each gene mutation in developing these cardiovascular disorders. We suggest considering the genetic mechanisms of cardiovascular diseases associated with hyperlipidemia, myocardial hypertrophy, or lethal arrhythmia in terms of not only clinical diagnosis but also understanding pathophysiology of each disease with therapeutic aspects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.