ArticleCerebellum (London, England)2013
MR diffusion histology and micro-tractography reveal mesoscale features of the human cerebellum.
Article in Cerebellum (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 60 citations in OpenAlex.
- Advancing Cerebro-cerebellar Network Imaging with Ultra-high Field (7T) MRI: Progress and Future Challenges.Cerebellum (London, England) · 2026Review
- Cerebellar pathway diffusion MRI measures are linked to core autism symptoms in early adolescents aged 9 to 11 years.Brain structure & function · 2026Article
- Anatomically constrained and curated cerebellar tractography (ACCURAT): an open framework and a pathway-specific neuroanatomical reference.bioRxiv : the preprint server for biology · 2026Article
- Region-specific mean field models enhance simulations of local and global brain dynamics.NPJ systems biology and applications · 2025Article
- Mesoscale connectivity of the human hippocampus and fimbria revealed by ex vivo diffusion MRI.NeuroImage · 2025Article
- Consistent cerebellar pathway-cognition associations across pre-adolescents & young adults: a diffusion MRI study of 9000+ participants.bioRxiv : the preprint server for biology · 2025Article
- Direct segmentation of cortical cytoarchitectonic domains using ultra-high-resolution whole-brain diffusion MRI.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Ex vivo 100 μm isotropic diffusion MRI-based tractography of connectivity changes in the end-stage R6/2 mouse model of Huntington's disease.Neuroprotection (Chichester, England) · 2023Article
- Acquisition and Analysis of Excised Neocortex from Pediatric Patients with Focal Cortical Dysplasia Using Mesoscale Diffusion MRI.Diagnostics (Basel, Switzerland) · 2023Article
- Magnetic resonance imaging at 9.4 T: the Maastricht journey.Magma (New York, N.Y.) · 2023Review
- Detection of functional activity in brain white matter using fiber architecture informed synchrony mapping.NeuroImage · 2022Article
- Atypical measures of diffusion at the gray-white matter boundary in autism spectrum disorder in adulthood.Human brain mapping · 2021Article
- Time-dependent diffusion MRI probes cerebellar microstructural alterations in a mouse model of Down syndrome.Brain communications · 2021Article
- Ex vivo mesoscopic diffusion MRI correlates with seizure frequency in patients with uncontrolled mesial temporal lobe epilepsy.Human brain mapping · 2020Article
- Brain networks and their relevance for stroke rehabilitation.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2019Review
- Ex vivo diffusion MRI of the human brain: Technical challenges and recent advances.NMR in biomedicine · 2019Article
- Article
- Visualization of nerve fibers around the carotid bifurcation with use of a 9.4 Tesla microscopic magnetic resonance diffusion tensor imaging with tractography.Head & neck · 2018Article
- Article
- High resolution anatomical and quantitative MRI of the entire human occipital lobe ex vivo at 9.4T.NeuroImage · 2018Article
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Authors and funding
5 authors at 4 institutions in 2 countries.
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Abstract
After 140 years from the discovery of Golgi's black reaction, the study of connectivity of the cerebellum remains a fascinating yet challenging task. Current histological techniques provide powerful methods for unravelling local axonal architecture, but the relatively low volume of data that can be acquired in a reasonable amount of time limits their application to small samples. State-of-the-art in vivo magnetic resonance imaging (MRI) methods, such as diffusion tractography techniques, can reveal trajectories of the major white matter pathways, but their correspondence with underlying anatomy is yet to be established. Hence, a significant gap exists between these two approaches as neither of them can adequately describe the three-dimensional complexity of fibre architecture at the level of the mesoscale (from a few millimetres to micrometres). In this study, we report the application of MR diffusion histology and micro-tractography methods to reveal the combined cytoarchitectural organisation and connectivity of the human cerebellum at a resolution of 100-μm (2 nl/voxel volume). Results show that the diffusion characteristics for each layer of the cerebellar cortex correctly reflect the known cellular composition and its architectural pattern. Micro-tractography also reveals details of the axonal connectivity of individual cerebellar folia and the intra-cortical organisation of the different cerebellar layers. The direct correspondence between MR diffusion histology and micro-tractography with immunohistochemistry indicates that these approaches have the potential to complement traditional histology techniques by providing a non-destructive, quantitative and three-dimensional description of the microstructural organisation of the healthy and pathological tissue.
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